Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume.
This is a timely resource for both early-career and established researchers working on mechanobiology.
- Provides an essential digest of primary research from many fields and disciplines in one convenient volume
- Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives
- Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science
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Table of Contents
1. Techniques for Studying Mechanobiology 2. Cell geometric control of nuclear dynamics and its implications 3. MechanobiologyThroughout Development 4. Cartilage Mechanobiology: how chondrocytes respond to mechanical load 5. Advances in Tendon Mechanobiology 6. Bone Mechanobiology in Health and Disease 7. Vascular Mechanobiology, Immunobiology, and Arterial Growth and Remodeling 8. Mechanobiology of the Heart Valve Interstitial Cell: Simulation, Experiment, Discovery 9. Platelet receptor-mediated mechanosensing and thrombosis 10. Mechanobiology of primary cilia in the vascular and renal systems 11. Neuromechanobiology 12. Mechanobiology of the eye 13. Gastrointestinal mechanosensory function in health and disease 14. Mechanobiology of Skin Diseases and Wound Healing 15. Mechanobiology of Metastatic Cancer