Pub. Date:
Springer Netherlands
Mechanosensitivity and Mechanotransduction / Edition 1

Mechanosensitivity and Mechanotransduction / Edition 1

by Irina Kiseleva, Andre Kamkin


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Product Details

ISBN-13: 9789048198801
Publisher: Springer Netherlands
Publication date: 12/01/2010
Series: Mechanosensitivity in Cells and Tissues , #4
Edition description: 2011
Pages: 371
Product dimensions: 6.10(w) x 9.25(h) x 0.24(d)

Table of Contents

Foreword Holger Scholz v

Editorial Andre Kamkin Irina Kiseleva vii

Contributors xxi

Part I The Role of Cytoskeleton in Mechanosensitivity and Mechanotransduction

1 Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells Kay-Pong Yip Lavanya Balasubramanian James S.K. Sham 3

2 The Role of the Actin Cytoskeleton in Mechanosensation Tianzhi Luo Douglas N. Robinson 25

3 Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts Qiang Fu Yiping Zhang Yajuan Xu Yourui Li Ling Guo Minfeng Shao 67

4 Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction Emma J. Blain 77

Part II Molecular Mechanisms of Mechanotransduction and Ion Channels Modulation

5 The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart Victor Kazanski Andre Kamkin Ekaterina Makarenko Natalia Lysenko Natalia Lapina Irina Kiseleva 109

6 Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart Danny Guo Zamaneh Kassiri Gavin Y. Oudit 141

7 Atomistic Molecular Simulation of Gating Modifier Venom Peptides - Two Binding Modes and Effects of Lipid Structure Kazuhisa Nishizawa 167

Part III Mechanosensitivity and Mechanotransduction in Vascular Cells

8 Cellular and Molecular Effects of Mechanical Stretch on Vascular Cells Kou-Gi Shyu 193

9 Role of Proteoglycans in Vascular Mechanotransduction Aaron B. Baker 219

Part IV Mechanotransduction in the Lung

10 Control of TRPV4 and Its Effect on the Lung James C. Parker Mary I. Townsley 239

11 The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury Matthew Rubacha Mingyao Liu 255

Part V Mechanosensing and Mechanotransduction in Bone and Joint Tissues

12 Cellular Mechanisms of Mechanotransduction in Bone Suzanne R.L. Young Fredrick M. Pavalko 277

13 The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases Christelle Sanchez Marianne Mathy-Hartert Yves Henrotin 297

Part VI Mechanotransduction of Sensor System

14 Primary Cilia are Mechanosensory Organelles in Vestibular Tissues Surya M. Nauli Hanan S. Haymour Wissam A. Aboualaiwi Shao T. Lo Andromeda M. Nauli 317

Part VII Mechanosensitivity and Mechanotransduction in Blood Cells

15 Mechanosensitive K+ Channels in Mouse B Lymphocytes: PLC-Mediated Release of TREK-2 from Inhibition by PIP2 Sung Joon Kim Joo Hyun Nam 353

Index 369

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