Medical Biochemistry at a Glance / Edition 3

Medical Biochemistry at a Glance / Edition 3

by J. G. Salway
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Medical Biochemistry at a Glance / Edition 3

Offering a concise, illustrated summary of biochemistry and itsrelevance to clinical medicine, Medical Biochemistry at aGlance is intended for students of medicine and the biomedicalsciences such as nutrition, biochemistry, sports science, medicallaboratory sciences, physiotherapy, pharmacy, physiology,pharmacology, genetics and veterinary science. It also provides asuccinct review and reference for medical practitioners andbiomedical scientists who need to quickly refresh their knowledgeof medical biochemistry.

The book is designed as a revision guide for students preparingfor examinations and contains topics that have been identified as'high-yield' facts for the United States Medical LicensingExamination (USMLE), Step 1.

This third edition:

  • Has been thoroughly revised and updated and is now in fullcolour throughout
  • Is written by the author of the hugely successful Metabolismat a Glance (ISBN 9781405107167)
  • Features updated and improved clinical correlates
  • Expands its coverage with a new section on MolecularBiology
  • Includes a brand new companion website of self-assessmentquestions and answers at

Product Details

ISBN-13: 9780470654514
Publisher: Wiley
Publication date: 02/21/2012
Series: At a Glance Series
Edition description: New Edition
Pages: 176
Product dimensions: 8.60(w) x 10.80(h) x 0.50(d)

About the Author

Dr Jack Salway- School of Biological Sciences, University of Surrey.

Table of Contents

Preface to the third edition 7

Acknowledgements to the third edition 7

Figure key 8

SI/mass unit conversions 9

Part 1 Acids, bases and pH

1 Acids, bases and hydrogen ions (protons) 10

2 Understanding pH 12

3 Production and removal of protons into and from the blood14

4 Metabolic alkalosis and metabolic acidosis 16

5 Respiratory alkalosis and respiratory acidosis 18

Part 2 Structure of amino acids and proteins

6 Amino acids and the primary structure of proteins 20

7 Secondary structure of proteins 22

8 Tertiary and quaternary structure and collagen 24

Part 3 Formation of ATP: oxidation and reductionreactions

9 Oxidation/reduction reactions, coenzymes and prosthetic groups26

10 Anaerobic production of ATP by substrate-levelphosphorylation, from phosphocreatine and by the adenylate kinase(myokinase) reaction 28

11 Aerobic production of ATP 30

12 Biosynthesis of ATP by oxidative phosphorylation I 32

13 Biosynthesis of ATP by oxidative phosphorylation II 34

14 What happens when protons or electrons leak from therespiratory chain? 36

15 Free radicals, reactive oxygen species and oxidative damage38

16 Aerobic oxidation of glucose to provide energy as ATP 40

17 Anaerobic oxidation of glucose by glycolysis to form ATP andlactate 42

18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG)and the Bohr effect 44

Part 4 Carbohydrates

19 Carbohydrates 46

20 Absorption of carbohydrates and metabolism of galactose48

21 Fate of glucose in liver: glycogenesis and lipogenesis 50

22 Fructose metabolism 52

23 Glucose homeostasis 54

24 Glucose-stimulated secretion of insulin from β-cells56

25 Regulation of glycogen metabolism 58

26 Glycogen breakdown (glycogenolysis) and glycogen storagediseases 60

27 Insulin signal transduction and diabetes mellitus 62

28 Diabetes mellitus 64

29 Alcohol metabolism: hypoglycaemia, hyperlactataemia andsteatosis 66

Part 5 Enzymes and regulation of pathways

30 Enzymes: nomenclature, kinetics and inhibitors 68

31 Regulation of enzyme activity 70

32 Regulation of glycolysis and Krebs cycle 72

33 Oxidation of fatty acids to produce ATP in muscle and ketonebodies in liver 74

34 Regulation of lipolysis, β-oxidation, ketogenesisand gluconeogenesis 76

Part 6 Lipids and lipid metabolism

35 Structure of lipids 78

36 Phospholipids I: phospholipids and sphingolipids 80

37 Phospholipids II: micelles, liposomes, lipoproteins andmembranes 82

38 Metabolism of carbohydrate to cholesterol 84

39 VLDL and LDL metabolism I: “forward” cholesteroltransport 86

40 VLDL and LDL metabolism II: endogenous triacylglyceroltransport 88

41 HDL metabolism: “reverse” cholesterol transport90

42 Absorption and disposal of dietary triacylglycerols andcholesterol by chylomicrons 92

43 Steroid hormones: aldosterone, cortisol, androgens andoestrogens 94

Part 7 Metabolism of amino acids and porphyrins

44 Urea cycle and overview of amino acid catabolism 96

45 Non-essential and essential amino acids 98

46 Amino acid metabolism: to energy as ATP; to glucose andketone bodies 100

47 Amino acid disorders: maple syrup urine disease,homocystinuria, cystinuria, alkaptonuria and albinism 102

48 Phenylalanine and tyrosine metabolism in health and disease104

49 Products of tryptophan and histidine metabolism 106

50 Haem, bilirubin and porphyria 108

Part 8 Vitamins

51 Fat-soluble vitamins I: vitamins A and D 110

52 Fat-soluble vitamins II: vitamins E and K 112

53 Water-soluble vitamins I: thiamin, ribofl avin, niacin andpantothenate 114

54 Water-soluble vitamins II: pyridoxal phosphate (B6) 116

55 Water-soluble vitamins III: folate and vitaminB12 118

56 Water-soluble vitamins IV: biotin and vitamin C 120

Part 9 Molecular biology

57 The cell cycle 122

58 Pyrimidine metabolism 124

59 Purine metabolism 126

60 Structure of DNA 128

61 The “central dogma” of molecular biology 130

62 Organisation of DNA in chromosomes 132

63 Replication of DNA (part 1) 134

64 Replication of DNA (part 2) 136

65 DNA damage and repair 138

66 Transcription of DNA to make messenger RNA (part 1) 140

67 Transcription of DNA to make messenger RNA (part 2) 142

68 Transcription of DNA to make transfer RNA 144

69 Transcription of DNA to make ribosomal RNA 146

70 Translation and protein synthesis 148

71 Comparison of DNA replication, DNA transcription and proteinsynthesis in eukaryotes and prokaryotes 150

Part 10 Diagnostic clinical biochemistry

72 Diagnostic clinical biochemistry (with Dr J. W. Wright FRCP,MRCPath) 152

Index 154

What People are Saying About This

From the Publisher

“It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic.” (The Bulletin of The Royal College of Pathologists, 1 January 2013)

“It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic.” (The Bulletin of The Royal College of Pathologists, 1 January 2013)

Clinical Pathology for the Veterinary Team will help experienced veterinary technicians set up various clinical laboratory diagnostic tests. It provides a good explanation of basic laboratory practices, the underlying concepts of many laboratory tests, and the physiology of common disease conditions. This book is well worth the price. (Journal of the American Veterinary Medical Association, December 2010) This book provides a good overall summary of basic clinical pathology in small animals. Although it is fairly short and concise, it contains all the necessary relevant information and includes a CD that takes readers thorough six complicated cases, step by step. This is a useful book that would be a handy reference to have in a practice. It is easy to read, concise, and informative. Although it is aimed at small animal veterinary teams, it includes limited information about large animal species, which is important for a good, general understanding. (Doodys, December 2010) Clinical Pathology for the Veterinary Team offers a fine recourse for technical team members involved in clinical diagnostic evaluation. Machinery calibration, normal anatomy, clinical diagnostics and more are revealed in chapters that provide key technical information for Obtaining and evaluating samples, surveying the disease process, the progress of identification and treatment, and including a DVD with interactive cases. Vet collections need this! (THE MIDWEST BOOK REVIEW, November 2010) Rosenfeld, a veterinarian who is associated with an education corporation that specializes in seminar training for the hospital team, and Dial (veterinary science and microbiology, U. of Arizona) provide a resource for technical veterinary team members performing clinical diagnostic evaluation in small animal lab work. (Book News, September 2010) ReviewUpdater-Profile_27@1326747466735

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