ISBN-10:
1607614995
ISBN-13:
9781607614999
Pub. Date:
03/10/2010
Publisher:
Springer-Verlag New York, LLC
Membrane Receptors, Channels and Transporters in Pulmonary Circulation / Edition 1

Membrane Receptors, Channels and Transporters in Pulmonary Circulation / Edition 1

by Jason X. -J. Yuan, Jeremy P. T. Ward

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Product Details

ISBN-13: 9781607614999
Publisher: Springer-Verlag New York, LLC
Publication date: 03/10/2010
Series: Advances in Experimental Medicine and Biology , #661
Edition description: 2010
Pages: 501
Product dimensions: 6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Part I Ion Channels in the Pulmonary Vasculature: Basics and New Findings

The Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction
E. Kenneth Weir, Jésus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, and Zhigang Hong

Two-Pore Domain K+ Channels and Their Role in Chemoreception
Keith J. Buckler

Intricate Interaction Between Store-Operated Calcium Entry and Calcium-Activated Chloride Channels in Pulmonary Artery Smooth Muscle Cells
Abigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, and Normand Leblanc

The Role of Intracellular Ion Channels in Regulating Cytoplasmic Calciumin Pulmonary Arterial Mmooth Muscle: Which Store and Where?
A. Mark Evans

Ca2+ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells
Michael J. Sanderson, Yan Bai, and Jose Perez-Zoghbi

Part II TRP Channels in the Pulmonary Vasculature:Basics and New Findings

Introduction to TRP Channels: Structure, Function, and Regulation
Michael Y. Song and Jason X.-J. Yuan
Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells
Xiao-Ru Yang, Mo-Jun Lin, and James S. K. Sham

The Contribution of TRPC1 and STIM1 to Capacitative Ca2+ Entry in Pulmonary Artery
Lih Chyuan Ng, Judith A. Airey, and Joseph R. Hume

Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1
Donna L. Cioffi, Christina Barry, and Troy Stevens

TRPM2 Channel Regulates Endothelial Barrier Function
Claudie M. Hecquet, Gias U. Ahmmed, and Asrar B. Malik

Part III Pathogenic Role of Ion Channels in Pulmonary Vascular Disease

A Proposed Mitochondrial–Metabolic Mechanism for Initiation and Maintenance of Pulmonary Arterial Hypertension in Fawn-Hooded Rats: The Warburg Model of Pulmonary Arterial Hypertension
Jalees Rehman and Stephen L. Archer

The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary
Vasoconstriction
B.Fuchs, A. Dietrich, T. Gudermann, H. Kalwa, F. Grimminger, and N. Weissmann

Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature
David N. Cornfield

Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle
Larissa A. Shimoda

CLC-3 Chloride Channels in the Pulmonary Vasculature
Joseph R. Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, and Dayue Duan

Part IV Receptors and Signaling Cascades in Pulmonary Arterial Hypertension

Role of Bone Morphogenetic Protein Receptors in the Development of Pulmonary Arterial Hypertension
Nicholas W. Morrell

Cross Talk Between Smad, MAPK, and Actin in the Etiology of Pulmonary Arterial Hypertension
James West

Notch Signaling in Pulmonary Hypertension
Patricia A. Thistlethwaite, Xiaodong Li, and Xiaoxue Zhang

Rho Kinase-Mediated Vasoconstriction in Pulmonary Hypertension
Ivan F. McMurtry, Kohtaro Abe, Hiroki Ota, Karen A. Fagan, and Masahiko Oka

The Serotonin Hypothesis of Pulmonary Hypertension Revisited
Margaret R. MacLean and Yvonne Dempsie

Impaired Vascular Endothelial Growth Factor Signaling in the Pathogenesis of Neonatal Pulmonary Vascular Disease
Steven H. Abman

Part V Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction

Mitochondrial Regulation of Oxygen Sensing
Navdeep S. Chandel

Reactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-Induced
Pulmonary Hypertension
Thomas C. Resta, Brad R. S. Broughton, and Nikki L. Jernigan

Polyamine Regulatory Pathways as Pharmacologic Targets in Pulmonary Arterial Hypertension
Mark N. Gillespie, and Jack W. Olson

5-HT Receptors and KV Channel Internalization
Angel Cogolludo and Francisco Perez-Vizcaino
Part VI Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease

KCNQ Potassium Channels: New Targets for Pulmonary
Vasodilator Drugs? Alison M. Gurney, Shreena Joshi, and B

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