Quick Look Metabolism integrates biochemical pathways with themes traditionally covered in physiology, cell structure, histology, and nutrition. Medical students at all levels will find this approach invaluable, especially when trying to grasp the big picture of human metabolism.
By integrating multidisciplinary concepts into a concise format, emphasis has been placed on basic principles, functions, and regulation with minimal attention given to metabolic intermediates and tedious structural details. Consideration of particular pathways include descriptions of the function the pathway plays in the cell or the organism as a whole; descriptions of the key reactions in the pathway, including where the reactions occur in the cell; and discussions of the organ specificity of the pathway, how it is regulated, and how it is co-ordinated with other pathways so that homeostasis is maintained. To provide vertical integration, clinical examples are used frequently to emphasise the connection between disease and abnormalities in metabolism.
Table of Contents
Part I: Fundamentals of Metabolism.
Cellular Organelles and Their Metabolic Functions.
Biological Buffers and Acid-Base Equilibrium.
Collagen: The Major Connective Tissue Protein.
Membrane Structure and Transport Proteins.
Hemoglobin Structure and Function.
General Properties of Enzymes.
Regulation of Enzyme Activity.
Transduction of Hormone Signals Across Membranes.
Nutritional Basis of Metabolism: Macronutrients.
Nutritional Basis of Metabolism: Micronutrients.
Part II: Bioenergetics .
Thermodynamic Principles of Metabolism.
Catabolic Functions of the TCA Cycle.
Anabolic Functions of the TCA Cycle.
Electron Transport Chain: Oxidation of NADH and FADH.
Oxidative Phosphorylation: Mitochondrial ATP Synthesis.
Interconversion of Metabolic Fuels.
Part III: Carbohydrate Metabolism.
Digestion and Absorption of Carbohydrate.
Effects of Insulin on Blood Glucose.
Effects of Glucagon on Blood Glucose.
Metabolic Fate of Pyruvate.
Coordinate Regulation of Glycogen Metabolism.
Coordinate Regulation of Glycolysis and Gluconeogenesis.
Pentose Phosphate Pathway.
Galactose, Fructose, and Glucuronic Acid Metabolism.
Glycosylation of Proteins.
Part IV: Lipid Metabolism.
Lipid Digestion and Absorption.
Structure and Function of Lipoprotiens.
VLDL, IDL, and LDL Metabolism.
Cholesterol and Bile Acid Metabolism.
Steroid Hormone Metabolism.
Fatty Acid Mobilization and Oxidation.
Coordinate Regulation of Fatty Acid Metabolism.
Sphingolipid and Glycolipid Metabolism.
Essential Fatty Acids and Eicosanoid Metabolism.
Part V: Amino Acid and Nitrogen Metabolism