Microdialysis in Drug Development

Microdialysis in Drug Development

by Markus Müller (Editor)


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Product Details

ISBN-13: 9781489996213
Publisher: Springer New York
Publication date: 10/15/2014
Series: AAPS Advances in the Pharmaceutical Sciences Series , #4
Edition description: 2013
Pages: 340
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

About the Author

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

Table of Contents

Introduction to the Microdialysis Technology.- Recovery and Calibration Techniques: Toward Quantitative Microdialysis.- Analytical Considerations for Microdialysis Sampling.- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective.- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations.- Microdialysis in Antibiotic Research.- Skin and Transdermal Drug Delivery: Advantages and Challenges.- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis.- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease.- Microdialysis in Pain Research.- Microdialysis in Ocular Drug Development.- Microdialysis in Metabolic Research.- High Molecular Weight Targets and Treatments Using Microdialysis.- Complementary Techniques – Positron Emission Tomography.- Open Flow Microperfusion: An Alternative Method to Microdialysis?.- Microdialysis in Internal Organs and Tumors.

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