Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.
- Describes the origin and molecular biology of pandemic influenza, HIV1, and HIV2 as well as the recent work on papillomaviruses, herpesviruses, BSE, and variant CJD
- Contains the latest data on tuberculosis, microbial evasion of immune defenses, and the spread of antibiotic resistance genes among bacteria
- Provides an update on vaccines, prions, immune evasion, and microbial ligands and receptors
- Gives an up-to-date picture of the global burden of infectious diseases
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About the Author
Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.Dr. Dalziel gained his BSc (Honours) in Biochemistry from the University of Glasgow in 1980. He then carried out his PhD studies on protein/DNA interactions in HSV-1 infected cells at the MRC Institute for Virology in Glasgow, graduating in 1984. He carried out post-doctoral research at the Scripps Research Institute, La Jolla CA, and in 1987 accepted a faculty position at the University of Edinburgh where he is now a senior lecturer and group leader in the Roslin Institute, Royal (Dick) School of Veterinary Studies.
Dr. Dalziel’s research interests focus on the mechanism of virus pathogenesis with a particular interest in herpesviruses. He has almost 30 years of experience in teaching undergraduate veterinary science and medical students and has designed and developed a number of undergraduate courses. He has supervised over 20 Graduate students and has served as a member of the UK Government Advisory Committee on Genetic Manipulation (ACGM). He is also Editor in Chief of Veterinary Research Communications.Dr. J. Ross Fitzgerald is the principle investigator for the Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases based at the College of Medicine and Veterinary Medicine, University of Edinburgh. The laboratory is focused on the use of genomic and molecular tools to examine the evolution and pathogenesis of clinically important species of Staphylococci. Dr. Fitzgerald has published numerous papers in peer-reviewed research journals.
Table of Contents
- General Principles
- Attachment to and Entry of Microorganisms into the Body
- Events occurring Immediately After the Entry of the Microorganism
- The Encounter with the Phagocytic Cell and the Microbe’s Answers
- The Spread of Microbes through the Body
- The Immune Response to infection
- Microbial Strategies in Relation to the Immune Response
- Mechanisms of Cell and Tissue Damage
- Recovery from Infection
- Failure to Eliminate Microbe
- Host and microbial factors influencing Susceptibility
- Vaccines and how they work