Modern Epidemiologic Principles and Concepts: Guidelines for Study Design, Conduct and Application

by Laurens Holmes

Overview

This novel text describes the basics of research in medical, and clinical settings as well as the concepts and application of epidemiologic designs in research conduct, as well as the implication of aberrant epigenomic modulations in disease etiology, prognosis, survival and mortality. Design transcends statistical techniques, and no matter how sophisticated a statistical modeling, errors of design/sampling cannot be corrected. Research is presented as an exercise around measurement, with measurement error inevitable in its conduct, hence the inherent uncertainties of all findings in clinical and medical research. Additionally, this book provides very basic explanation on how to examine the data collected for research conduct for the possibility of confounding and how to address such confounders, thus disentangling effects for reliable and valid inference. The last chapter very clearly describes the environmental determinants of disease process, implying DNA sequence and environmental interaction as aberrant epigenomic modulations in disease causation as etiology, therapeutics, prognosis, survival and mortality at the population level.

Product Details

ISBN-13:	9798341896918
Publisher:	Barnes & Noble Press
Publication date:	02/14/2025
Pages:	384
Product dimensions:	7.00(w) x 10.00(h) x 0.79(d)

About the Author

Laurens Holmes Jr specialized in Immunology & Infectious Disease as a component of Internal Medicine, as well as Neuro- Pharmacology. Currently he is an expert in Cancer Epidemiology and Biostatistical modeling, namely Signal Amplification and Risk Specific Stratification (SARSSm) with specific focus on epigenomic epidemiology. Dr. Holmes is a major proponent of aberrant epigenomic modulations in disease incidence, morbidity, prognosis, mortality and survival. This specialized discipline, epigenomic epidemiology was developed by Professor Holmes, in the application of aberrant epigenomic modulations in cancer risk determinants and induction therapy prior to the standard of care in malignant neoplasm. He is currently developing an epigenomic device in specific gene expression identification, and the application in genomic and epigenomic modulations in disease causation.

Dr. Holmes was a former Head of the Epidemiology Laboratory at the Nemours Center for Childhood Cancer Research, Wilmington, former Professor of Molecular Epidemiology and Clinical Trials at University of Delaware, USA. Professor Holmes, former director of Clinical & Translational Science Institute, Medical College of Wisconsin, Milwaukee has trained medical students, residents, fellows (doctorate/post-doctorate), and junior faculty on the application of epigenomic modulations in disease causation, therapeutics as induction therapy prior to the standard of care. He is currently the Editor-in-Chief, Pediatric Health, Medicine & Therapeutics, and Precision Medicine Research scientific journals. Dr. Holmes has published intensively in several scientific journals and several books in epidemiology, biostatistics, public health and, clinical medicine. Professor Holmes is currently the Director of the Graduate Public Health Program, Delaware State University, Dover, USA and Distinguished Professor, Public Health Institute, FAMU, Tallahassee, FL.