Molecular Biology: Principles and Practice / Edition 2 available in Hardcover
Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped—and who continue to shape—the field today.
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|Publisher:||Freeman, W. H. & Company|
|Edition description:||Second Edition|
|Product dimensions:||8.60(w) x 11.00(h) x 1.40(d)|
About the Author
Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science.
Michael O'Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O'Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O'Donnell is a member of the National Academy of Sciences.
Table of Contents
I. Foundations1. Evolution, Science, and Molecular Biology2. DNA: The Repository of Biological Information3. Chemical Basis of Information Molecules4. Protein Structure5. Protein FunctionII. Nucleic Acid Structure and Methods6. DNA and RNA Structure7. Studying Genes8. Genomes, Transcriptomes, and Proteomes9. Topology: Functional Deformations of DNA10. Nucleosomes, Chromatin, and Chromosome Structure III. Information Transfer11. DNA Replication12. DNA Mutation and Repair13. Recombinational DNA Repair and Homologous Recombination14. Site-Specific Recombination and Transposition15. Transcription: DNA-Dependent Synthesis of RNA16. RNA Processing17. The Genetic Code18. Protein SynthesisIV. Regulation19. Regulating the Flow of Information20. The Regulation of Gene Expression in Bacteria21. The Transcriptional Regulation of Gene Expression in Eukaryotes22. The Posttranscriptional Regulation of Gene Expression in EukaryotesAppendix: Model Organisms GlossarySolutions to ProblemsIndex