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Freeman, W. H. & Company
Molecular Cell Biology / Edition 5

Molecular Cell Biology / Edition 5

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Molecular Cell Biology is a perspective on living systems that arose from the union of three other disciplines: biochemistry, genetics and anatomical cell biology. Molecular Cell Biology provides a comprehensive, authoritative introduction to the current state of knowledge in this dynamic field. In the fourth edition, the authors have introduced new pedagogy for the reader, streamlined coverage, and integrated media and text to provide students in upper division cell and molecular biology courses with the clearest possible understanding of cell function at the molecular and cellular level. Founded on the work of scientists past and present, the experimental techniques that have generated their data, and the key concepts that inform our understanding of biology, the fourth edition of Molecular Cell Biology will be the most up-to-date text available.

New to this edition:

  • Coverage streamlined to illustrate points with a select few paradigmatic examples and/or experiments, eliminate redundancies, and delete rarely used chapters and sections. Topics traditionally spread over several chapters have been consolidated.
  • Increased pedagogical support and flexibility to help the student easily find, review, and master the material. For example, major sections are numbered, begin with an overview, and conclude with a bulleted summary that brings the student "up for air." Supplements are now organized by section, rather than by chapter (see Supplements).
  • New discoveries include genome sequencing and the human genome project (Ch. 7), DNA "chip" microarray technology (Ch. 7), chromosome "painting" (Ch. 9), newly-identified tumor suppressorgenes, SNARES and other proteins involved in vesicular traffic, development in the model organism Arabidopsis (Ch. 14), activation of gene expression triggered by cell surface receptors, essential features of cell-sgnalling pathways (Ch. 20) and detecting chromosomal translocations in cancer cells (Ch. 24)
  • New chapter on cell interactions in development (Ch. 23)
  • Consistent art program: All art has been rendered for a consistent look and feel across the book and between text figures and animations on the CD-ROM.
  • Increased student interest features include:
    • Medical, biotech, and plant biology applications that are highlighted in context
    • MCAT/GRE-style questions for self-testing
    • "Perspectives for the Future" sections that explore the potential applications of future discoveries and the unanswered questions that lie ahead in research.
    • "Perspectives in the Literature" sections that send students to the original literature to answer complex thought questions.

Product Details

ISBN-13: 9780716743668
Publisher: Freeman, W. H. & Company
Publication date: 08/28/2003
Edition description: Fifth Edition
Pages: 973
Product dimensions: 8.74(w) x 11.02(h) x 1.56(d)

About the Author

Harvey Lodish is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF-ß receptors. His lab also studies hematopoietic stem cells and has identified novel proteins that support their proliferation. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology.
Arnold Berk is Professor of Microbiology, Immunology and Molecular Genetics and a member of the Molecular Biology Institute at the University of California, Los Angeles. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the original discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription nitiation in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. He teaches introductory courses in molecular biology and virology and an advanced course in cell biology of the nucleus.
Chris A. Kaiser is Professor and Head of the Department of Biology at the Massachusetts Institute of Technology. His laboratory uses genetic and cell biological methods to understand the basic processes of how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top undergraduate educator at MIT, where he has taught genetics to undergraduates for many years.
Monty Krieger is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for the movement of cholesterol into and out of cells, including the HDL receptor.
Anthony Bretscher is Professor of Cell Biology at Cornell University. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton, and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. Dr. Bretscher teaches cell biology to graduate students at Cornell University.
Hidde Ploegh is Professor of Biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. One of the world’s leading researchers in immune system behavior, Dr. Ploegh studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune system distinguishes friend from foe. Dr. Ploegh teaches immunology to undergraduate students at Harvard University and MIT.
Angelika Amon is Professor of Biology at the Massachusetts Institute of Technology, a member of the Koch Institute for Integrative Cancer Research, and Investigator at the Howard Hughes Medical Institute. She is also a member of the National Academy of Sciences. Her laboratory studies the molecular mechanisms that govern chromosome segregation during mitosis and meiosis and the consequences—aneuploidy—when these mechanisms fail during normal cell proliferation and cancer development. Dr. Amon teaches undergraduate and graduate courses in cell biology and genetics.
Matthew P. Scott is Professor of Developmental Biology, Genetics and Bioengineering at Stanford University School of Medicine and Investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and a past president of the Society for Developmental Biology. He is known for his work in developmental biology and genetics, particularly in areas of cell-cell signaling and homeobox genes and for discovering the roles of developmental regulators in cancer. Dr. Scott teaches cell and developmental biology to undergraduate students, development and disease mechanisms to medical students and developmental biology to graduate students at Stanford University

Kelsey Martin is Professor of Biological Chemistry and Psychiatry and interim Dean of the David Geffen School of Medicine at the University of California, Los Angeles. She is the former Chair of the Biological Chemistry Department Her laboratory studies the ways in which experience changes connections between neurons in the brain to store long-term memories—a process known as synaptic plasticity. She has made important contributions to elucidating the molecular and cell biological mechanisms that underlie this process. Dr. Martin teaches basic principles of neuroscience to undergraduates, graduate students, dental students, and medical students.

Table of Contents

IChemical and Molecular Foundations
1Life Begins with Cells1
2Chemical Foundations29
3Protein Structure and Function59
4Basic Molecular Genetic Mechanisms101
IICell Organization and Biochemistry
5Biomembranes and Cell Architecture147
6Integrating Cells into Tissues197
7Transport of Ions and Small Molecules Across Cell Membranes245
8Cellular Energetics301
IIIGenetics and Molecular Biology
9Molecular Genetic Techniques and Genomics351
10Molecular Structure of Genes and Chromosomes405
11Transcriptional Control of Gene Expression447
12Post-transcriptional Gene Control and Nuclear Transport493
IVCell Signaling
13Signaling at the Cell Surface533
14Signaling Pathways That Control Gene Activity571
15Integration of Signals and Gene Controls611
VMembrane Trafficking
16Moving Proteins into Membranes and Organelles657
17Vesicular Traffic, Secretion, and Endocytosis701
18Metabolism and Movement of Lipids743
19Microfilaments and Intermediate Filaments779
VIICell-Cycle and Cell-Growth Control
21Regulating the Eukaryotic Cell Cycle853
22Cell Birth, Lineage, and Death899

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