Molecular Genetics of Liver Neoplasia

Molecular Genetics of Liver Neoplasia


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Molecular Genetics of Liver Neoplasia by Xin Wei Wang

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepaellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.

Product Details

ISBN-13: 9781461427315
Publisher: Springer New York
Publication date: 12/25/2012
Series: Cancer Genetics Series
Edition description: 2011
Pages: 399
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

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