Multiple Sclerosis: An Analysis of 812 Cases by Means of Electronic Data Processing

Multiple Sclerosis: An Analysis of 812 Cases by Means of Electronic Data Processing

by Sigrid Poser

Paperback(Softcover reprint of the original 1st ed. 1978)

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The value of prospective long-term studies on the features and course of multiple sclerosis is determined by the reliability with which relevant infor­ mation is documented. This involves two basic problems: I) The docu­ mentation system used must be detailed enough to provide adequate data on the essential features and course of the disease in a given case; on the other hand, it must not be so complicated and cumbersome as to preclude its use in the routine care of MS patients. 2) Since no system can fully anticipate new problems and scientific approaches that may become impor­ tant at some future time, the system must be open to provide the possi­ bility of adding and correlating the data of special research studies with the . basic data. These considerations led to the development of the basic documentation system described here and employed for the analysis of clinical data in this monograph. The work was carried out with the help of the Deutsche Forschungsgemeinscha/t as a part of its research program on multiple sclerosis and related demyelinating disease. A basic documentation pool including the data of more than 2 000 patients has been accumulated in the last six years. The system has been put to practical use in a number of epidemiologic surveys completed or under way, in following up the cases in an epidemiologic observation area in South Lower Saxony, and in studies on spasticity, cerebrospinal fluid findings, clinical forms and neuro­ physiological aspects of MS.

Product Details

ISBN-13: 9783642875700
Publisher: Springer Berlin Heidelberg
Publication date: 03/30/2012
Series: Schriftenreihe Neurologie Neurology Series , #20
Edition description: Softcover reprint of the original 1st ed. 1978
Pages: 96
Product dimensions: 6.69(w) x 9.61(h) x 0.01(d)

Table of Contents

1. Introduction.- 1.1 The Need for a New Documentation System.- 1.2 Current Methods of Documentation in General Neurology.- 1.3 Documentation of Special Neurologic Diseases.- 2. Methods.- 2.1 Different Forms of Documentation.- 2.1.1 Punched Cards.- 2.1.2 Modern Methods.- 2.2 Choice of Documentation Method for Multiple Sclerosis.- 2.2.1 Development of the Documentation Sheet for Multiple Sclerosis.- 2.2.2 Handling of the Sheet.- 2.3 Quality Control of the Data.- 2.4 Management of the Forms.- 2.4.1 The Process of Registration.- 2.4.2 Description of the Program.- 2.4.3 Access to the Data.- 2.4.4 Correction of Errors.- 2.5 Analysis of the Data.- 2.6 Distribution of the Data.- 2.7 The New Set of Documentation Sheets.- 2.8 Statistical Methods.- 2.8.1 Significance Tests.- 2.8.2 Graphic Presentation.- 3. Results.- 3.1 Size of the Study.- 3.2 Comments on the Method.- 3.2.1 Analysis of Errors.- 3.2.2 The Precision of Recording.- 3.2.3 Free Text.- 3.2.4 Validity of the System.- 3.3 Documentation of Disease Course.- 3.4 Analysis of All Examinations Performed.- 3.5 Analysis of First Examinations.- 3.5.1 Month of Onset.- 3.5.2 Age at Onset, Present Age, and Differences Between Males and Females.- 3.5.3 Disturbances of the Functional Systems.- 3.5.4 Selection of Certain Groups.- 3.5.5 Statistical Analysis of Symptoms.- 3.6 Correlations.- 3.6.1 Correlation Between Mental Changes and Other Disturbances.- 3.6.2 Duration of Disease and Symptoms.- 3.6.3 Duration of Disease and Performance.- 3.6.4 Age at Onset and Performance.- 3.6.5 Disease Course and Performance.- 3.6.6 Analysis of Bouts.- 3.7 Diagnostic Classification.- 3.8 Laboratory Results.- 3.8.1 CSF Findings.- 3.8.2 Serologic Studies.- 3.9 Different Samples.- 3.9.1 The Epidemiologic Study.- 3.9.2 Subgroups.- 4. Discussion.- 4.1 Clinical Questions.- 4.1.1 Prognosis.- 4.1.2 The Problem of Diagnosis.- 4.1.3 Statistics on Signs and Symptoms.- 4.1.4 Follow-Up Examinations.- 4.2 Critical Comments on the Method.- 4.3 The Contribution of the New Documentation System to MS Research.- 5. Outlook.- 5.1 Neuropathology.- 5.2 Virology.- 5.3 Immunology.- 5.4 Relevance of CSF Findings.- 5.5 Epidemiology.- 5.6 The Standardized Medical Record.- Summary.- References.

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