Description: This book addresses different aspects of the debilitating disease of myeloma, including epidemiology, biology, pathogenesis, diagnosis, and treatment, and reviews other plasma cell dyscrasia such as POEMS syndrome, Castleman disease, amyloidosis, and Waldenstrom macroglobulinemia.
Purpose: The purpose is to provide a deeper understanding of the disease biology, from cell cycle regulation, signaling pathways, genetic and epigenetic changes to the role of bone marrow microenvironment, with six chapters dedicated to these topics. The book provides a collective understanding of the disease biology and descriptions of carefully designed clinical studies. It reviews the recent advances in the diagnosis and treatment of the disease and provides an important source of information for clinicians and scientists in the field.
Audience: The book is written for healthcare professionals, including physicians, nurse practitioners, scientists, and researchers. The authors are the expert authorities in the field.
Features: The strength of the book is its clear presentation of the existing knowledge of the biology of the disease and diagnosis. The short, well-written chapters include figures, tables, graphs, and imaging studies useful for conceptualizing the information. Treatment strategies are summarized based on pivotal phase II and randomized phase III studies with relevant references. However, two important areas of ongoing research in the treatment of the disease are missing. One is the exciting and accumulating data on the role of minimal residual disease (MRD). Although this is mentioned in the first chapter under diagnosis, its influence in predicting outcome and directing therapeutic decisions in the near future requires an in-depth discussion in the treatment chapter. The second topic is the active research into using new targeted agents and radiation technology (i.e. IMRT) as conditioning regimens in the field of transplantation. These areas of research among many others are important in advancing the field.
Assessment: This is a well-written and well-structured book focused on disease biology, which is the backbone of present and future treatment strategies. It is an important source of information for both clinicians and researchers.