Prepared by leading scientists in the field, these volumes compile for the first time, concise, up-to-date reviews of several aspects of the basic properties, distribution, function and regulation of the Na+/H+ antiport. In addition, current methods and the use of inhibitors and ligands for the study of the exchanger are described. These volumes are indispendable to researchers and students in the areas of ion transport, membrane biology and cellular physiology.
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Table of Contents1. pH-Selective Microelectrodes: construction and Use in Investigations of Transmembrane Sodium/Hydrogen Exchange 2. Measurement of pH and Na+ by Nuclear Magnetic Resonance. Part 1: Basic Properties and Distributing of The Na+/H+ Exchanger 3. Methods for the Study of Na+/H+ Exchange: Ion Fluxes and Ion-Selective Electrodes 4. Kinetics of Na+/H+ Exchange 5. Na+/H+ Ex-change in Excitable Cells 6. Properties of Na+/H+ Exchange in Excitable Cells 7. Na+/H+ Exchange in Bacteria and Organelles Part 2: Inhibitors and Ligands Of The Na+/H+ Exchanger 8. Amiloride: Chemistry, Kinetics, and Structure-Activity Relationships. Part 3: Physiological Role of The Na+/H+ Exchanger 9. Basic Principles of pH Regulation 10. The Role of the Na+/H+ Antiport in Cardiac Cells, Skeletal Muscle Cells, Neurona Cells and Glial Cells 11. Physiological Role of Na+/H+ Exchange in Epithelial Cells 12. Na+/H+ Exchange and Volume Regulation in Nonepithelial Cells 13. Symports and Antiports and Epithelial Cell Volume Regulation 14. Coupling between Na+/H+ and Cl-/HCO3 Exchange in pH and Volume Regulation 15. The Role of Na+/H+ Exchange and Intracellular pH Changes in Fertilization Part 4: Regulation Of Na+/H+ Exchange: Rapid Effectors 16. Effects of Growth Factors on Na+/H+ Exchange 17. Phorbol Esters and the Regulation of Na+/H+ Exchange 18. Regulation of Na+/H+ Exchange: Role of Ca2+ 19. Effects of Catecholamines and Cyclic Nucleotides on Na+/H+ Exchange 20. Effects of Neutrophil and Platelet Activators 21. Action of Insulin on Na+/H+ Exchange. Part 5: Regulation Of Na+/H+ Exchange: Slow (Adaptive) Effectors 22. Regulation of Na+/H/up Exchange Activity by Adaptive Mechanisms 23. Chronic Adaption of Na+/H+ Exchange in Renal Disease Part 6: Genetic Studies Of Na+/H+ Exchange 24. Molecular Genetics of the Mammalian Na+/H+ Antiporter