Pub. Date:
Springer US
Neuropharmacology and Behavior

Neuropharmacology and Behavior

by Bernard Haber


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Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich's influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich's research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

Product Details

ISBN-13: 9781461339632
Publisher: Springer US
Publication date: 10/14/2011
Edition description: 1978
Pages: 224
Product dimensions: 5.98(w) x 9.02(h) x 0.02(d)

Table of Contents

1 • Amphetamine Psychosis-A Model for Paranoid Schizophrenia?.- 1. Introduction.- 1.1. LSD as a Drug Model.- 1.2. Amphetamine as a Drug Model.- 2. Clinical Description.- 2.1. Differences and Similarities.- 2.2. Experimental Induction.- 2.3. Metabolism.- 3. Speculation.- 3.1. Mechanism.- 3.2. Anatomical Substrate.- 3.3. Stress.- 3.4. Chronic-Acute Differences.- 3.5. Amine-Interaction Etiology.- 3.6. Other Conditions Associated with Paranoia.- 4. Conclusion.- 5. References.- 2 • Hypersensitive Serotonergic Receptors Involved in Clinical Depression-A Theory.- 1. Introduction.- 2. Two Serotonergic Models of Depression Based on Drug- Induced Atypical Behavior in Animals.- 2.1. A Tryptophan-5-Hydroxytryptophan Model.- 2.2. A Tetrabenazine Model.- 3. Selective Review of Clinical Studies Involving the Cerebral Serotonergic System and Depressive Illness in Man.- 4. A Theory Suggesting the Presence of Hypersensitive Serotonergic Synapses in Clinical Depression.- 5. Final Comments.- 6. References.- 3 • The Organization of Central Catecholamine Neuron Systems.- 1. Introduction.- 2. Dopamine Neuron Systems.- 2.1. Nigrostriatal System.- 2.2. Mesocortical System.- 2.3. Tubero-Hypophysial System.- 2.4. Incerto-Hypothalamic System.- 2.5. Retinal System.- 2.6. Periventricular System.- 3. Noradrenaline Systems.- 3.1. Locus Coeruleus System.- 3.2. Lateral Tegmental System.- 4. Adrenaline System.- 5. Conclusions.- 6. References.- 4 • Effect of Reserpine on Monoamine Synthesis and on Apparent Dopaminergic Receptor Sensitivity in Rat Brain.- 1. Introduction.- 2. Methods.- 3. Results.- 3.1. Dose Response.- 3.2. Time Course.- 3.3. Effect of Apomorphine after Pretreatment with Reserpine.- 4. Discussion.- 5. Summary.- 6. References.- 5 • The Induction of Tyrosine-3-monooxygenase in Rat Adrenal Medulla: A Model for the Transsynaptic Regulation of Gene Expression.- 1. Introduction.- 2. Measurements of TH Synthesis Rate in Rat Adrenal Medulla.- 3. Participation of 3?,5?-Adenosine Monophosphate in the Transsynaptic Regulation of Gene Expression in Rat Adrenal Medulla.- 4. Protein Kinase Activation and cAMP Content in Rat Adrenal Medulla.- 5. Inconsistency of the Experimental Evidence Supporting a Lack of Correlation Between an Early Increase in cAMP Content and the Delayed Transsynaptic Induction of Medullary TH.- 5.1. Experiments with Swimming Stress.- 5.2. Experiments with Reserpine and Propanolol.- 5.3. Experiments with Dexamethasone and Reserpine.- 5.4. Experiments with Reserpine: A Dose-Response Relationship.- 6. Activation and Translocation of Protein Kinase from Adrenal Medulla Cytosol During Transsynaptic Induction of TH.- 7. Protein Kinase Translocation in Explaining Results Purporting a Lack of Association Between Increase in cAMP and TH Induction.- 8. Nuclear Phosphorylation and Gene Expression: Role of Protein Kinase Translocation.- 9. Conclusions.- 10. References.- 6 • The Neurophysiological Effects of Diphenylhydantoin and Their Relationship to Anticonvulsant Activity.- 1. Introduction.- 2. Active Transport and Electrolyte Balance.- 2.1. Biochemical Studies.- 2.2. Ouabain Antagonism.- 2.3. Frog Skin Preparation.- 2.4. Neurophysiological Studies.- 3. Neurophysiological Studies.- 3.1. Invertebrate Preparation.- 3.2. Mammalian Preparations.- 4. Discussion and Conclusions.- 5. References.- 7 • Some Molecular Aspects of Neural Mechanisms.- 1. Introduction.- 2. Molecular Structure of Receptors for Transmitters.- 3. Molecular Structure of the Sodium Channel.- 4. Molecular Structure of Nucleohistone.- 4.1. Histone H4.- 4.2. Histone H3.- 4.3. Histone H2B.- 4.4. Histone H2A.- 5. Possible Structures for the Nucleosome.- 6. References.- 8 • Seven Neurons of Psychopharmacology: Adaptive Regulation in Biogenic Amine Neurons.- 1. Introduction.- 2. Seven Model Neurons.- 2.1. Model Neuron 1.- 2.2. Model Neuron 2.- 2.3. Model Neuron 3.- 2.4. Model Neuron 4.- 2.5. Model Neuron 5.- 2.6. Model Neuron 6.- 2.7. Model Neuron 7.- 3. Discussion and Speculation.- 4. References.- Epilogue.- Bibliography of Harold E. Himwich.

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