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NMR: Principles and Applications to Biomedical Research
     

NMR: Principles and Applications to Biomedical Research

by Jay W. Pettegrew (Editor)
 

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Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who

Overview

Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who demonstrated that a beam of hydrogen molecules in the presence of a magnetic field could be mutated by radio frequency fields resonating at the Iarmor frequency. 'Ihe first successful NMR experiments in condensed matter were independently conducted in late 1945 by Purcell, Torrey and PoUnd and by Bloch, Hansen and Packard. 'Ihe Purcell group detected proton NMR in solid paraffin and the Bloch group detected proton in liquid water. Bloch and Purcell received the Nobel Prize in physics in 1952 for these observations . Until about 1952, studies of liquids and solids with broad resonance lines dominated the field of NMR. However, the reports of 3 1 P NMR chemical shifts in several corrpounds in 1949 by Khight, of 14 N resonances in several ions by Proctor and Yu in 1950, and of 1 9 F resonances in several corrpounds in 1950 by Dickinson led to the development of high resolution NMR in Itquids. since the molecular motions in liquids result in very narrow lines compared to those in solids, :much smaller chemical shifts could be detected.

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Booknews
An overview of the fundamental theory and principles of nuclear magnetic resonance (NMR), also demonstrating the application of these principles to major biomedical research, including in vivo spectroscopy, spectroscopy of tumor and brain components, NMR imaging techniques and applications, and NMR imaging in psychiatry. For researchers in biology, biomedicine, neurology, and biological psychiatry. Acidic paper. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9781461279570
Publisher:
Springer New York
Publication date:
12/31/2013
Edition description:
Softcover reprint of the original 1st ed. 1990
Pages:
618
Product dimensions:
6.10(w) x 9.25(h) x 0.05(d)

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