Notch Signaling in Embryology and Cancer

Notch Signaling in Embryology and Cancer


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Product Details

ISBN-13: 9781461408987
Publisher: Springer New York
Publication date: 12/28/2011
Series: Advances in Experimental Medicine and Biology , #727
Edition description: 2012
Pages: 322
Product dimensions: 7.01(w) x 10.00(h) x 0.04(d)

About the Author

JÖRG REICHRATH is Professor for Dermatology and Deputy Director of the Clinic for Dermatology, Allergology and Venerology at the Saarland University Hospital in Homburg/Saar, Germany. Main research interests include photobiology, dermato-endocrinology and dermato-oncology. He is a member of numerous national and international scientific organizations, including the German Dermatological Society (DDG), the Deutsche Krebsgesellschaft (DKG), the German Dermatologic Cooperative Oncology Group (DeCOG), and the European Society of Dermatological Research (ESDR). He has been awarded numerous prices including the Arnold-Rikli-price 2006. Jörg Reichrath received his academic degrees (Dr. med., venia legendi) from the Saarland University, Germany.

SANDRA REICHRATH is working as a scientist at the Clinic for Internal Medicine of the Saarland University Hospital in Homburg/Saar, Germany. Main research interests include Notch signalling in glioblastoma and skin tumors. She received her academic degrees from the Faculty of Biology of the Albert-Ludwig-University, Freiburg, Germany.

Table of Contents

The Molecular Basis of Notch Signaling: A Brief Overview.- The Role of Adams in Notch Signaling.- Metabolism and Transportation Pathways of GDP‑Fucose that are Required for the O‑Fucosylation of Notch.- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages.- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex.- Notch Signaling and Development of the Hematopoietic System.- Notch Signaling in Lung Development and Disease.- The Role of Notch Signaling in Kidney Development and Disease.- Notch Signaling and the Developing Skeleton.- Notch Signaling and the Developing Skin Epidermis.- Notch Signaling and the Developing Hair Follicle.- Notch Signaling and the Developing Inner Ear.- Notch Signaling in Cancer Stem Cells.- Notch Signaling Pathway and Cancer Metastasis.- Notch, Apoptosis and Cancer.- Ligand‑Dependent Notch Signaling in Vascular Formation.- Notch and the P53 Clan of TranscriptionFactors.- Notch Signaling and Breast Cancer.- Notch Signaling and Malignant Melanoma.- Notch‑Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited.- Notch Signaling and Intestinal Cancer.- Notch Signaling and Brain Tumors.- Notch Inhibition as a Promising New Approach to Cancer Therapy.

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