This book is about a discovery termed "preactivation" that is considered a major breakthrough in photodynamic therapy and in drug development. The process of preactivation generates previously unknown chemotherapeutic agents that are not only effective against malignancies and viral infections, but are also easily tolerated.
Table of Contents1. Challenges and Opportunities in New Drug Development.- 2. Preactivation-Discovery and Biological Effects of Novel Chemotherapeutic Agents.- 3. Photochemistry and Photophysics of Merocyanine 540.- 4. Preclinical Studies of Preactivated Merocyanine 540 and Merodantoin.- 5. The Role of Topoisomerases and Apoptosis in the Mechanism of Action of Preactivated Compounds.- 6. Modulation of Oncogenes with Preactivated Compounds.- Epilogue.