Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity andLipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin,adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
Table of ContentsChapter 1. The Definition and Prevalence of Obesity and Metabolic Syndrome.-Chapter 2. Circadian Rhythms in Diet-induced Obesity.-Chapter 3. Eating and Death: Chronic Over-eating.-Chapter 4. Obesity and Persistent Organic Pollutants and Related Health Problems.-Chapter 5. Protein Kinases in Obesity.-Chapter 6. Fat cell and Fatty Acid Turnover in Obesity.-Chapter 7. Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome.-Chapter 8. What is Lipotoxicity.-Chapter 9. The Pathogenesis of Obesity-associated Adipose Tissue Inflammation.-Chapter 10. Obesity and Microbiota.-Chapter 11. Endoplasmic Reticulum Stress and Obesity.-Chapter 12. Insulin Resistance, Obesity-Lipotoxicity.-Chapter 13. Hypoxia and Adipose Tissue Dysfunction in Obesity.-Chapter 14. Adipocyte-macrophage Cross-talk in Obesity.-Chapter 15. Endothelial Dysfunction in Obesity.-Chapter 16. Diet Induced Obesity and the Mechanism of Leptin Resistance.-Chapter 17. Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity.-Chapter 18. Adiponectin and Adiponectin-resistance in Obesity.-Chapter 19. Non-alcoholic Fatty Liver Disease.-Chapter 20. Lipotoxicity-related Hematologic Disorders in Obesity.-Chapter 21. Micro-RNA and Adipogenesis.-Chapter 22. The Interactions Between Kynurenine and Pteridine Pathways in Obesity.-Chapter 23: Eligibility and Success Criteria for Bariatric/metabolic Surgery.-Chapter 24: Does Bariatric Surgery Improve the Lipotoxicity-related Complications of Obesity.-Chapter 25: Obesity-associated Breast Cancer: Analysis of Risk Factors .-Chapter 26: Lipotoxicity and Olive Oil in Obesity.