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In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.
Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
|Series:||Progress in Molecular Biology and Translational Science Series|
|Product dimensions:||6.30(w) x 9.00(h) x 1.10(d)|
About the Author
Terry P. Kenakin is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society. Having been involved in drug discovery for over 30 years, his interests include the optimal design of drug activity assays systems and quantitative drug receptor theory. He is a member of numerous editorial boards as well as Editor-in-Chief of the Journal of Receptors and Signal Transduction and Current Opinion in Pharmacology. In addition, Dr. Kenakin has authored numerous articles and has also written a number of books on pharmacology.
Table of Contents
- Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
- Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
- Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
- G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
- GPCRs in Stem Cell Function
- Application of Receptor Theory to Allosteric Modulation of Receptors
- What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
- Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
- Chemokine Receptor Oligomerization and Allostery
- Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac
Michael T. Klein, Paige N. Vinson and Colleen M. Niswender
Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender
Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis
Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri
Van A. Doze and Dianne M. Perez
David A. Hall
Frederick J. Ehlert
Bryan Stephens and Tracy M. Handel