ISBN-10:
1560724277
ISBN-13:
9781560724278
Pub. Date:
06/28/1999
Publisher:
Nova Science Publishers, Incorporated
On the Way to Individuality: Current Methodological Issues in Behavioral Genetics / Edition 1

On the Way to Individuality: Current Methodological Issues in Behavioral Genetics / Edition 1

by Michele C. LaBuda, Elena L. Grigorenko

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Product Details

ISBN-13: 9781560724278
Publisher: Nova Science Publishers, Incorporated
Publication date: 06/28/1999
Pages: 252
Product dimensions: 7.09(w) x 10.24(h) x (d)

Table of Contents

PrefaceIX
Section IIncorporating Development in the Search for Ethiological Factors in Human Traits
1.Adaptive and Maladaptive Pathways in Development: A Quantitative Genetic Perspective1
Introduction1
Normative vs. Pathological Development2
Individual Differences in Development4
Etiology of Individual Differences and Extreme Cases7
Resilience in Development14
Environmental Influences and Adaptive and Maladaptive Development15
Concluding Remarks18
References18
2.Variable Age of Gene Expression: Implications for Developmental Genetic Models23
Introduction23
Path Analytic Models for Behavior Genetic Studies of Developmental Change and Continuity23
Limitations of Current Path Analytic Developmental Models31
Variable Age at Gene Expression: A Simulation Study32
A Developmental Genetic Analysis of the Body Mass Index of Adolescent Twins40
Discussion48
References49
3.The Detection of Genotype-Environment Interaction in Longitudinal Genetic Models53
Introduction53
Summary of Results Relating to the Calculation of Individual Genetic and Environmental Factor Scores and Statistical Tests of Genotype-Environment Interaction55
Specification of the Genetic Simplex Model58
Interactions and Fourth-Order Moments in the Genetic Simplex Model61
Illustration Using Simulated Data63
Discussion67
References68
4.Twins Reared Apart: Nature's Double Experiment71
The Origin of the Twins Reared Apart Method71
Behavior Genetic Findings Confirmed by the Twins Reared Apart Method: Minimum Influence of the Shared Rearing Environment76
Genetic Influence on Environmental Variables80
Genotype x Environment Interactions84
Conclusion86
References87
5.The Iowa Adoption Studies: Methods and Results95
Introduction95
Rationale and Practical Application of the Adoption Separation Paradigm99
Techniques of Analysis of Adoption-Separation Data105
Specific Types of Separation-Adoption Paradigms106
The Iowa Adoption Studies: Adoptee Substance Abuse111
Reproducibility and Generalizability of Adoption Findings119
Future Direction of Adoption-Separation Paradigms120
References121
Section IIFamily, Twin and Adoption Studies: Diversity of Approaches
6.The Usefulness of Family Studies127
Introduction127
How Data From Family Studies Can Contribute Knowledge in Behavior Genetics128
Applications From a Family Sample133
Method134
Results138
The Inclusion of Data From a New Twin Panel148
Conclusions149
References151
7.Analysis of Familial Aggregation in a Binary Trait by Logistic Regression and the Regressive Logistic Model155
Introduction155
Background to the Examples156
Logistic Regression157
Measuring Association in a Binary Trait164
Use of Descriptive Measures of Association in Genetic Epidemiology167
The Regressive Logistic Model169
Discussion180
References182
Section IIISearching for Genes Involved in Beheviorial Expression
8.Genetic Analysis of Complex Diseases185
Conclusion204
References204
9.Whole-Genome Screening Using Third-Degree Relatives: Power to Detect Excess Allele- Sharing At a Predisposing Locus209
Whole-Genome Screening Using Third-Degree Relatives: Power to Detect Excess Allele-Sharingat a Predisposing Locus209
Model221
Results and Discussion221
Conclusions229
References230
10.Partitioning the Genetic Variation of Quantitative Traits Using Marker Loci235
Introduction235
Methods237
Discussion242
Acknowledgments245
References245
Index249

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