Pub. Date:
Springer-Verlag New York, LLC
Pancreatic Stem Cells / Edition 1

Pancreatic Stem Cells / Edition 1

by Juan Domïnguez-BendalaJuan Domïnguez-Bendala


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The aim of Pancreatic Stem Cells is to provide a broad overview of an intriguing model of organogenesis (the development of the pancreas) from the perspective of stem cell research. The tangible prospect of devising effective cell therapies for type I diabetes -a disease thus far considered incurable- has stoked a widespread interest in harnessing our knowledge on the basic biology behind the development of this organ. This text is conceived as an all-encompassing guide to explore the many aspects of "regenerative therapies" for the endocrine pancreas, from adult and embryonic stem cells to endogenous regeneration and transdifferentiation. All these themes are built upon an up-to-date discussion on pancreatic ontogeny, which provides a solid background for both basic scientists and health professionals. Written for: Stem cell biologists, cellular biologists, endocrinologists, embryologists, and biotechnologists

Product Details

ISBN-13: 9781607611318
Publisher: Springer-Verlag New York, LLC
Publication date: 07/01/2009
Series: Stem Cell Biology and Regenerative Medicine
Edition description: 2009
Pages: 154
Product dimensions: 6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Table of Contents:

Preface. Importance of the subject in the context of type I diabetes (2-3 pages)

The pancreas (15 pages)

Pancreatic development (50-60 pages)

Pancreatic regeneration (30-40 pages)

Models of regeneration

Stem cells vs. beta cell replication

Stem cell differentiation: general approaches (20-30 pages)

Recapitulation of pancreatic development

Signal-driven strategies

Gene transfer and protein transduction

Physiological variables

Embryonic stem cells and pancreatic differentiation (40 pages)

Adult stem cells and pancreatic differentiation (60 pages)

Bone marrow

Umbilical cord

Ductal and acinar cells

Mesenchymal stem cells and de-differentiation

Transdifferentiation (30 pages)

Remaining challenges and clinical perspectives (20-30 pages)

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