ISBN-10:
0896037614
ISBN-13:
9780896037618
Pub. Date:
04/20/2001
Publisher:
Springer-Verlag New York, LLC
Parkinson's Disease: Methods and Protocols / Edition 1

Parkinson's Disease: Methods and Protocols / Edition 1

by M. Maral Mouradian
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Product Details

ISBN-13: 9780896037618
Publisher: Springer-Verlag New York, LLC
Publication date: 04/20/2001
Series: Methods in Molecular Medicine , #62
Edition description: 2001
Pages: 317
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Part I. Genetics

Point Mutations in the _-Synuclein Gene
Abbas Parsian and Joel S. Perlmutter

Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis
Hiroto Matsumine, Nobutaka Hattori, and Yoshikuni Mizuno

Part II. Molecular Pathogenetic Studies

Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as _-Synucleinopathies
Michel Goedert, Ross Jakes, R. Anthony Crowther, and Maria Grazia Spillantini

_-Synuclein/Amyloid Interactions
Poul Henning Jensen

Functional Defect Conferred by the Parkinson's Disease-Causing _-Synuclein (Ala30Pro) Mutation
Poul Henning Jensen

Molecular Biology of Dopamine-Induced Apoptosis: Possible Implications for Parkinson's Disease
Ilan Ziv, Anat Shirvan, Daniel Offen, Ari Barzilai, and Eldad Melamed

Animal Models of Induced Apoptotic Death in the Substantia Nigra
Tinmarla F. Oo and Robert E. Burke

Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigra
Tinmarla F. Oo and Robert E. Burke

The Role of Nitric Oxide in Parkinson's Disease
Serge Przedborski and Ted M. Dawson

Oxidative Stress Indices in Parkinson's Disease: Biochemical Determination
Moussa B. H. Youdim, Noam Drigues, and Silvia Mandel

Part III. Molecular Aspects of Basal Ganglia Function

Quantification of Tyrosine Hydroxylase mRNA
Hiroshi Ichinose, Tamae Ohye, Takahiro Suzuki, Hidehito Inagaki, and Toshiharu Nagatsu

Immunochemical Analysis of Dopamine Transporters in Parkinson's Disease
Gary W. Miller and Allan I. Levey

Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice: Implications for Parkinson's Disease
Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, and Marc G. Caron

Transcription Mechanisms for Dopamine Receptor Genes
Sang-Hyeon Lee and M. Maral Mouradian

Detection of DNA/Protein Interactions in Dopamine Receptor Genes
Sang-Hyeon Lee and M. Maral Mouradian

In Situ Hybridization on Brain Tissue
Claas-Hinrich Lammers, Yoshinobu Hara, and M. Maral Mouradian

Regulation of Striatal N-Methyl-d-Aspartate Receptor (NMDAR) Function by Phosphorylation of Its Subunits in Parkinsonian Rats
Justin D. Oh

Part IV. Molecular Therapies

Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism
Richard Grondin, Zhiming Zhang, Dennis D. Elsberry, Greg A. Gerhardt, and Don M. Gash

Grafting Genetically Engineered Cells into the Striatum of NonHuman Primates
Krys S. Bankiewicz, Phillip Pivirotto, Rosario Sanchez-Pernaute, and Eugene O. Major

Encapsulated Cell Implants as a Novel Treatment for Parkinson's Disease
Jack L. Tseng and Patrick Aebischer

Neural Stem Cell Technology as a Novel Treatment for Parkinson's Disease
Richard J. E. Armstrong, Anne E. Rosser, Stephen B. Dunnett, and Roger A. Barker

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