Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art compendium on a very recent branch of tumor biology. It offers an awareness and understanding of germ cell tumors: from the earliest stages to their va- rious differentiations. Original data for this volume was supplied by experts in the fields of pathology, developmental biology, genetics, molecular biology and other related fields. This compilation of knowledge provides information necessary to persons working in clinical and preclinical areas.
Table of ContentsOverview.- Pathobiology of Human Germ Cell Neoplasia.- Cells of Origin.- Carcinoma in Situ of the Testis: Possible Origin, Clinical Significance, and Diagnostic Methods.- Characterization of Precancerous and Neoplastic Human Testicular Germ Cells.- Cytogenetic Investigation of Gonadal Carcinomas in Situ in Syndromes of Abnormal Sexual Differentiation.- Cell Lines.- Human Embryonal Carcinoma and Yolk Sac Carcinoma in Vitro: Cell Lineage Relationships and Possible Paracrine Growth Regulatory Interactions.- Biochemical Analysis and Cellular Location of the GCTM-2 Antigen in Embryonal Carcinoma and in Other Tumour Cell Lines.- Differentiation Antigens.- The Surface Antigen Phenotype of Human Embryonal Carcinoma Cells: Modulation Upon Differentiation and Viral Infection.- Lactate Dehydrogenase Isoenzyme 1 in Testicular Germ Cell Tumors.- Expression of Developmentally Regulated Genes in Embryonal Carcinoma Cells.- Chromosomal Studies.- Cytogenetic Studies of Testicular Germ Cell Tumors: Pathogenetic Relevance.- Isochromosome (12p) in Germ Cell Tumors.- Molecular Genetics.- Molecular Analysis of Isochromosome 12p in Testicular Germ Cell Tumors.- Analysis of Chromosome 12 Abnormalities in Male Germ Cell Cancers.- Frequent Occurrence of Activated ras Oncogenes in Seminomas but Not in Nonseminomatous Germ Cell Tumors.- Differential Activation of Homeobox Genes by Retinoic Acid in Human Embryonal Carcinoma Cells.- Growth Factors and Their Receptors.- Growth Factors and the Control of Human Teratoma Cell Proliferation.- Role of Heparin-Binding Growth Factors in Embryonic Tumors.- Growth Factors and Receptors During Differentiation: A Comparison of Human and Murine Embryonal Carcinoma Cell Lines.- Growth Factors in Human Germ Cell Cancer.