Pathogenic Fungi available in Hardcover
In recent years the development of new molecular biology tools and the elucidation of whole genome sequences have revolutionized research on pathogenic fungi. Such advances have led to the development of faster, more reliable diagnostic techniques for medically important pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. In addition they have led to a major breakthrough in the approach for the generation of novel anti-fungal agents. Now it is possible to search for agents that target essential genes. Research in this area has never been more exciting.
In this book a panel of expert international mycologists critically review the most important cutting-edge topics. Chapters are written from a molecular and genomic perspective and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. Topics include: gene expression and regulation, heterozygosity in Candida, molecular diagnosis, regulation of the host-fungal interaction, the development of anti-fungals, signal transduction, and mechanisms of multi-drug resistance.
Essential reading for everyone with an interest in pathogenic fungi including: mycologists, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.
|Publisher:||Caister Academic Press|
|Product dimensions:||6.40(w) x 9.50(h) x 1.10(d)|
Table of Contents
1 Gene Expression and Regulation Carol Munro Bernhard Hube 9
2 Heterozygosity and Loss of Heterozygosity in Candida albicans German Larriba Richard A. Calderone 43
3 Regulatory Networks in the Host-Fungal Pathogen Interactions L. Fernandes A.L. Bocca A.M. Ribeiro S.S. Silva H.C. Paes A.C. Amaral V.L.P. Polez N.F. Martins C.M.A. Soares M.S.S. Felipe 77
4 The Candida Immunome as a Mine for Clinical Biomarker Development for Invasive Candidiasis: From Biomarker Discovery to Assay Validation Aida Pitarch Cesar Nombela Concha Gil 111
5 MAP Kinase Pathways in Pathogenic Fungi: Elements, Roles and Interactions David M. Arana Rebeca Alonso-Monge Elvira Roman Cesar Nombela Jesus Pla 151
6 Molecular Approaches to Target Drug Discovery in Human Pathogenic Fungi Neeraj Chauhan Richard Calderone 171
7 Genome-wide Approaches to Understand Multi-drug Resistance in Pathogenic Fungi Amelie Waldin Nitnipa Soontorngun Sarah MacPherson Sadri Znaidi Martine Raymond Bernard Turcotte 195
8 New Approaches in the Diagnosis of Medically Relevant Mycoses: Fungal Identification by Molecular Techniques Gioconda San-Blas Gustavo Nino-Vega 225