Pathophysiology of Severe Ischemic Myocardial Injury

Pathophysiology of Severe Ischemic Myocardial Injury

by H.M. Piper (Editor)

Paperback(Softcover reprint of the original 1st ed. 1990)

$98.10 $109.00 Save 10% Current price is $98.1, Original price is $109. You Save 10%.
View All Available Formats & Editions
Use Standard Shipping. For guaranteed delivery by December 24, use Express or Expedited Shipping.

Product Details

ISBN-13: 9789401066990
Publisher: Springer Netherlands
Publication date: 09/26/2011
Series: Developments in Cardiovascular Medicine , #104
Edition description: Softcover reprint of the original 1st ed. 1990
Pages: 440
Product dimensions: 6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

I: Introduction.- 1. Irreversible ischemic injury: definition of the problem.- 2. Recovery of severely ischemic myocardium: a challenge for the clinical cardiologist.- II: The Role of Energy Deficiency.- 3. The critical ATP threshold hypothesis.- 4. Importance of glycolytically produced ATP for the integrity of the threatened myocardial cell.- III: The Search for Critical Cellular Structures.- 5. Loss of sarcolemmal integrity in ischemic myocardium.- 6. Mitochondrial injury in the oxygen-depleted and reoxygenated myocardial cell.- 7. Lysosomal integrity in ischemic, hypoxic and recovering heart.- IV: The Role of Lipids.- 8. Detrimental effects of fatty acids and their derivatives in ischemic and reperfused myocardium.- 9. Hydrolysis of phospholipids and cellular integrity.- 10. Eicosanoids and the ischemic myocardium.- V: The Role of Oxygen Radicals.- 11. Importance of free radicals generated by endothelial and myocardial cells in ischemia and reperfusion.- 12. The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium.- 13. Problems associated with reperfusion of ischemic myocardium.- VI: The Role of Calcium.- 14. Subcellular calcium shifts in ischemia and reperfusion.- 15. Causes and effects of changes in cytosolic free calcium in the hypoxic myocardial cell.- VII: Mechanical Factors: Rigor and Contracture.- 16. Rigor and contracture, the role of phosphorus compounds and cytosolic calcium.- 17. Importance of mechanical factors in ischemic and reperfusion injury.- VIII: The Role of Endothelial Cells and Neurons.- 18. Sensitivity of the endothelium to hypoxia and reoxygenation.- 19. Release and effects of catecholamines in myocardial ischemia.- IX: Conclusions.- 20. Severe ischemic myocardial injury: Perspectives for therapy.

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews