Pub. Date:
Springer Netherlands
Peroxiredoxin Systems: Structures and Functions / Edition 1

Peroxiredoxin Systems: Structures and Functions / Edition 1

by Leopold Flohé, J. Robin Harris
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The peroxiredoxins represent an important emerging family of sulfhydryl-linked antioxidant proteins, apparently ubiquitously present in all known organisms. The antioxidant function of the peroxiredoxins complements that of other enzymic and non-enzymic systems within the cell. In addition, there is increasing evidence that the peroxiredoxins play a role in cell signalling, by controlling and/or sensing hydrogen peroxide and peroxynitrite levels.

In this, the first book containing a broad survey on the peroxiredoxins, the editors succeeded to involve almost all groups that contributed significant insights into the emerging field. The diverse biological roles of the new protein family are discussed in the context of other antioxidant systems like those based on heme or selenium catalysis. Finally, related future perspectives, which range from antimicrobial therapy up to the understanding of human development and carcinogenesis, are highlighted. Specifically, the book will be of outstanding interest to researchers who want to understand how micro-organisms, plants and animals cope with oxidative stress and how such stress is recognized and linked to adaptive responses via redox regulation of cellular processes.

Product Details

ISBN-13: 9781402060502
Publisher: Springer Netherlands
Publication date: 11/09/2007
Series: Subcellular Biochemistry , #44
Edition description: 2007
Pages: 408
Product dimensions: 6.20(w) x 9.30(h) x 0.80(d)

Table of Contents

Contributing Authors
Preface Chapter 1. Introduction: History of the Peroxiredoxins and Topical Perspectives
Leopold Flohé and J. Robin Harris Chapter 2. Evolution of the Peroxiredoxins (Taxonomy/Homology/Characterization)
Bernard Knoops, Eléonore Loumaye and Valérie Van der Eecken Chapter 3. Structural Survey of the Peroxiredoxins
P. Andrew Karplus and Andrea Hall Chapter 4. The Catalytic Mechanism of Peroxiredoxins
Leslie B. Poole Chapter 5. Kinetics of Peroxiredoxins and their Role in the Decomposition of Peroxynitrite
Madia Trujillo, Gerardo Ferrer-Sueta, Leonor Thomson, Leopold Flohé and Rafael Radi Chapter 6. The Peroxiredoxin Repair Proteins
Thomas J. Jönsson and W. Todd Lowther Chapter 7. Peroxiredoxins in Bacterial Antioxidant Defense
James M. Dubbs and Skorn Mongkolsuk Chapter 8. The NADH oxidase-Prx system in Amphibacillus xylanus
Youichi Niimura Chapter 9. Peroxiredoxin Systems in Mycobacteria
Timo Jaeger Chapter 10. Peroxiredoxin systems of protozoal parasites
Marcel Deponte, Stefan Rahlfs and Katja Becker Chapter 11. The Trypanaothione System
Luise R. Krauth-Siegel, Marcelo A. Comini and Tanja Schlecker Chapter 12. Functions of Typical 2-Cys Peroxiredoxins in Yeast
Brian A. Morgan and Elizabeth A. Veal Chapter 13. The Dual Function of Plant Peroxiredoxins in Antioxidant Defence and Redox Signaling
Karl-Josef Dietz Chapter 14. Mitochondrial Peroxiredoxins: Structure and Function
Zhenbo Cao, J. Gordon Lindsay and Neil W. Isaacs Chapter 15. Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI
Bruno Schremmer, Yefim Manevich, Sheldon I. Feinstein, and Aron B. Fisher. Chapter 16. Peroxiredoxins in Gametogenesis andEmbryo Development
Isabelle Donnay and Bernard Knoops Chapter 17. Peroxiredoxins in the Central Nervous System
Fumiyuki Hattori and Shinzo Oikawa Chapter 18. Stress-induced Peroxiredoxins
Tetsuro Ishii and Toru Yanagawa Index

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