ISBN-10:
0471496375
ISBN-13:
9780471496373
Pub. Date:
04/18/2002
Publisher:
Wiley
Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules / Edition 1

Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules / Edition 1

by Christine Bladon

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Overview

Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules / Edition 1

Pharmaceutical Chemistry:Therapeutic Aspects of Biomacromolecules offers a comprehensive and balanced introduction to this exciting and rapidly developing subject. Key strategies involved in the development and production of a range of clinically useful compounds are presented along with a broad overview of the way in which peptides, proteins, nucleic acids and carbohydrates are used therapeutically.

Illustrated with numerous examples, the book covers essential compounds and explains how they exert their influence through an understanding of biological processes. Pharmaceutical chemistry has become progressively more important in terms of both research and teaching, and this new book includes latest developments with examples carefully selected in order to emphasise the molecular basis of specific disease processes

Features:
* a comprehensive introduction to this evolving field
* numerous examples and problems focusing on fundamental concepts and ideas to enhance student understanding
* coverage of various strategies behind the development and production of a range of key clinically useful compounds This book will be invaluable to all students of chemistry, pharmacy, medicinal and pharmaceutical chemistry and pharmacology. It will also be of interest to researchers and professionals needing a concise, up-to-date account of this subject.

Product Details

ISBN-13: 9780471496373
Publisher: Wiley
Publication date: 04/18/2002
Pages: 234
Product dimensions: 6.71(w) x 9.69(h) x 0.54(d)

Table of Contents

Prefaceix
Abbreviationsxi
1Introduction1
1.1Overview1
1.1.1Endocrine disorders2
1.1.2Severe combined immunodeficiency disorders2
1.2Biomacromolecules in the Treatment of Human Disease4
2Endogenous Peptides and Proteins7
2.1Overview7
2.2Isolation from Natural Tissues and Fluids11
2.3Synthesis and Semi-Synthesis12
2.3.1Peptide synthesis12
2.4Gene Cloning26
2.4.1Growth hormone37
2.5Transgenic Procedures39
2.6Examples of Direct Replacement Strategy40
2.6.1Insulin40
2.6.2The fibrin and fibrinolytic cascades46
3Modification of Endogenous Peptides and Proteins55
3.1Overview55
3.2Peptide Mimetics56
3.2.1Mimetics based on luteinizing hormone-releasing hormone62
3.2.2Mimetics based on somatostatin64
3.3Chemical Modification of Proteins67
3.3.1Immunoassays69
3.3.2Modification with synthetic polymers72
3.3.3Modification of enzyme active sites74
3.4Protein Engineering75
3.4.1Site-directed mutagenesis76
3.4.2Chimeric toxins78
3.4.3Chimeric and humanized antibodies80
3.4.4The single-chain Fv85
3.4.5Phage display87
4The Immune System95
4.1Overview95
4.2The Antibody-Mediated Response95
4.2.1Polyclonal antibodies95
4.2.2Monoclonal antibodies99
4.3Vaccines107
4.3.1Hepatitis B vaccine108
4.3.2Approaches to an HIV vaccine110
4.4The Cell-Mediated Immune Response114
4.4.1Immunoenhancement119
4.4.2Immunosuppression119
4.5Cancer Immunotherapy124
4.5.1Antibody-mediated immunotherapy125
4.5.2T-cell-mediated immunotherapy128
5Oligonucleotides135
5.1Overview135
5.2Gene Therapy136
5.2.1Introduction136
5.2.2Ex vivo gene delivery138
5.2.3Clinical applications143
5.3Antisense Therapy151
5.3.1Introduction151
5.3.2Development of an antisense oligonucleotide154
5.3.3Clinical studies163
5.4Ribozymes164
6Oligosaccharides169
6.1Overview169
6.2Oligosaccharide Synthesis171
6.3Heparin178
6.4Glycoproteins179
6.4.1Blood group oligosaccharides180
6.5Polysaccharide Bacterial Vaccines182
6.6Approaches to Carbohydrate-Based Cancer Vaccines182
Appendix191
A.1Amino Acids and Peptides191
A.1.1Abbreviations and structural representations191
A.1.2Secondary structures193
A.2Oligonucleotides, DNA and RNA196
A.3Carbohydrates199
Glossary203
Index215

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