Pub. Date:
Taylor & Francis
Pharmaceutical Dosage Forms and Drug Delivery

Pharmaceutical Dosage Forms and Drug Delivery

by Ram I. Mahato, Ajit S. Narang


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Product Details

ISBN-13: 9780849392856
Publisher: Taylor & Francis
Publication date: 06/01/2007
Series: Plant Engineering Series
Edition description: Older Edition
Pages: 336
Product dimensions: 6.20(w) x 9.30(h) x 0.90(d)

Table of Contents

Drug Development and Regulatory Process Introduction Identification of New Therapeutic Molecules Preclinical Research Formulation Development Regulatory Issues Pharmaceutical and Formulation Considerations Introduction Advantages of Pharmaceutical Dosage Forms Influential Factors in Dosage Form Design Biopharmaceutical and Physiological Considerations Introduction Drug Transport across a Polymeric Barrier Fick’s Laws of Diffusion Pore Diffusion Matrix (Monolithic)-Type Nondegradable Device Biological Membranes and Drug Absorption Dissolution Rate and Noyes–Whitney Equation of Dissolution Factors Influencing Dissolution Rate
Complexation and Protein Binding
Introduction Types of Complexation Drug Interaction with Plasma Proteins Binding Equilibria Impact of Plasma Protein Binding on Dosing Regimens Chemical Kinetics and Stability
Introduction Rates and Order of Reaction Factors Affecting Reaction Kinetics Pathways and Prevention of Chemical Decomposition of Drugs Interfacial Phenomena
Introduction Liquid Interfaces Adsorption at Solid–Gas Interfaces Adsorption at Solid–Liquid Interface Rheology
Introduction Newtonian Flow Non-Newtonian Flow Thixotropy Disperse System Basics
Introduction Types of Colloidal Systems Kinetic Properties of Colloids Electrical Properties Electrostatic Effect Electrical Double Layer Stability of Colloids Surfactants and Micelles
Introduction Surfactants HLB Systems Micelles Cloud Point
Pharmaceutical Suspensions
Introduction Classification of Suspensions Characteristics of Pharmaceutical Suspensions Formulation of Suspensions Flocculation and Deflocculation Pharmaceutical Emulsions
Introduction Advantages of Emulsion Dosage Forms Types of Emulsions Roles of Interfacial Free Energy on Emulsification Formulations of Emulsions Emulsifying Agents Pharmaceutical Solutions
Introduction pH and Solubility Buffer and Buffer Capacity Vehicles Types of Solutions Dry or Lyophilized Mixtures for Solution Tablets
Introduction Types of Tablets Tablet Formulation Powder Flow and Compressibility Manufacturing of Tablets Relationship among Disintegration, Dissolution, and Absorption Evaluation of Tablets
Introduction Hard Gelatin Capsules Soft Gelatin Capsules Evaluation of Capsules Injectable Dosage Forms
Introduction Isotonicity..
Parenteral Routes of Administration Formulation of Parenteral Products Sterilization of Parenteral Products Types of Parenteral Dosage Forms Evaluation of Injectable Products
Semisolid Dosage Forms
Introduction Ointments Creams Gels Lotions Pastes
Inserts, Implants, and Devices
Introduction Inserts Implants Suppositories Aerosol Products Transdermal Patches Pharmaceutical Polymers
Introduction Definitions and Architectures of Polymers Polymer Molecular Weight and Weight Distribution Biodegradablity and Biocompatibility Polymer Solubility Block Copolymers Intelligent or Stimuli-Sensitive Polymers Water-Soluble Polymers Bioadhesive/Mucoadhesive Polymers Drug Delivery Systems
Introduction Prodrugs Soluble Macromolecular Carriers Particulate Carrier Systems Oral Drug Delivery Alternative Routes of Delivery Protein-and Peptide-Based Dosage Forms
Introduction Structure of Peptides and Proteins Hydrophobicity of Peptides and Proteins Solubility of Peptides and Proteins Instability of Peptides and Proteins Formulation of Proteins and Peptides Antibody-Based Therapy and Delivery Antigenicity and Immunogenicity Biotechnology-Based Dosage Forms
Introduction Genes and Gene Expression Gene Silencing Classification of Gene-Silencing Technologies Gene Therapy Each chapter contains Learning Objectives, Review Questions, and a Bibliography.
Answers to Review Questions Index

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