We are pleased to present to our readers the Proceedings of the Sixth International Workshop on Phosphate and Other Minerals which was held in Verona, Italy, during June 24-26, 1983. It was hosted by Professor Giuseppe Maschio, Professor of Medicine and Chief, Department of Nephrology at the University of Verona. The Sixth Workshop maintained the tradition of the previous ones. It provided a unique and outstanding opportunity for close interaction between scientist involved in the research of the overall field of Mineral Metabolism. The current Workshop was attended by 250 scientists from 15 countries including Austria, Canada, Denmark, England, France, Germany,Holland, Israel, Italy, Japan, Spain, Sweden,Switzerland, and the United States of America. The topics discussed included the renal handling of phosphate, transport of other minerals, intestinal absorption of calcium and phosphate and phosphate homeostasis in health and disease. Two symposia dealing with the recent developments of the interactions between minerals, parathyroid hormone, and blood pressure and between minerals and myopathies were included. In addition to the 15 State-of-the-Art Lectures, there were 43 oral and 63 poster presentations selected from over 200 abstracts sub mitted to the Program Committee. The Seventh International Workshop on Phosphate and Other Minerals will be held during September, 1985, in Marseille, France. It will be hosted by Professor Michel almer, Chief of the Department of Nephrology at the University of Marseille. The theme of this coming Workshop will focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals.
Table of ContentsRenal Handling of Phosphate.- The Biochemical Modifications of the Brush Border Membrane Induced by Vitamin D and Parathyroid Hormone in Their Actions on Phosphate Transport.- Intracellular Processes that Affect Renal Phosphate Transport.- Effect of Serum Calcium on Phosphate Transport.- Influence of Temperature on Phosphate Uptake by Renal Brush Border Membrane Vesicles.- Parathyroid Hormone (PTH) Status and Phosphate (Pi) Transport in Proximal Brush Border Membrane Vesicles (BBMV) and Whole Kidney.- Renal Brush Border Membranes in X-Linked Hypophosphatemic Mice: A Study of the Protein Kinase Activity.- Biochemical Studies of the Control of Renal Tubular Phosphate Reabsorption.- Role of c-AMP and NAD in the Regulation of Na+ Dependent Phosphate Transport Across Rat Renal Brush Border Membranes.- Gluconeogenesis, Cytosolic Redox Potential, and Phosphate and Fluid Transport in the Tubule Isolated Rabbit Proximal.- Comparison of the Effect of Nucleotides on Phosphate Transport in Renal Brush Border Membrane Vesicles and Intact Proximal Tubules.- The Usefulness of Isolated Renal Cortical Cells to Study Phosphate Transport.- Calcium (Ca) Mediated Phosphate (PO4) Transport in the Proximal Convoluted Tubule (PCT) of the Rabbit.- Glucocorticoid-Induced Inhibition of the Reabsorption of Inorganic Phosphate in the Proximal Tubule in the Absence of Parathyroid Hormone.- Effect of 1,25-Dihydroxycholecalciferol on the Extrarenal Handling of Inorganic Phosphate in Thyroparathyroidectomized but not in Intact Rats.- Early Renal Adaptation to Dietary Phosphorus Restriction.- Phosphaturia of Aging: Studies on Mechanisms.- Calcium and Magnesium Transport.- The Assessment of Renal Calcium Reabsorption.- Cis-Platin Induced Hypermagnesiuria and Hypercalciuria in Rats.- Brush Border Vesicle Transport Effects of 1,25-Dihydroxy Vitamin D3.- Active Calcium Transport in Frog Skin: Stimulation by Cyclic AMP.- ATP as a Factor in the Response of the cAMP System to PTH in Proximal and Distal Convoluted Tubules.- Different Effects of Parathyroid Hormone on Epithelial Transport.- Intestinal Absorption of Phosphate and Calcium.- Verapamil Improves Defective Intestinal Calcium Absorption in Uremia.- Vitamin D Activates (Na+ -K+) ATPase: A Possible Regulation of Phosphate and Calcium Uptake by Cultured Embryonic Chick Small Intestine.- Effects of pH and Sodium on Phosphate Transport Across Brush Border Membrane Vesicles of Small Intestine.- Direct In Vitro Effects of 1,25(OH)2 Vitamin D3 on Phosphate Transport in Isolated Enterocytes from Normal or Vitamin D Deficient Rats.- 1,25-Dihydroxyvitamin D3 Stimulates Calcium and Phosphate Absorption by Different Mechanisms: Contrasting Requirements for Sodium.- Dissociation of Absorptions of Calcium and Phosphate in Different Pathophysiological States in Man.- Topics on Bone.- Bone Remodelling After Renal Transplantation (RT).- Inorganic Phosphate, Pyrophosphate and the Diphosphonates Activate Bone (Calvaria) Glutaminase.- Effect of Calcium-Sodium Exchange and Calcium Channel Inhibition on Calcium Release from Bone in an In-Vitro Bone Perfusion System.- Phosphate-Restricted Diets versus Calcitonin in the Prevention of Osteodystrophy in Experimental Renal Disease.- Changes Following Parathyroidectomy in Hemodialyzed Patients.- Minerals, Parathyroid Hormone and Blood Pressure.- Serum Ionized Calcium and Dietary Calcium in Human and Experimental Hypertension.- The Relationship Between Body Phosphate and Blood Pressure.- Interactions Between Mg and Blood Pressure.- Parathormone and Blood Pressure in the Spontaneously Hypertensive Rat.- Trifluoperazine Attenuation of PTH-Induced Vasodilation in the Spontaneously Hypertensive Rat.- Evidence of bPTH-(1-34) Sensitive Adenylate Cyclase in Isolated Rabbit Renal Cortex Arterioles.- The Effects of Changes in Serum Calcium and Parathormone on Plasma Renin Activity in Intact Mongrel Dogs.- Modification of the Renal Effects of Ouabain by Calcium Channel Blockers.- Importance of Calcium in the Renal Hemodynamic Changes Induced by Vanadate.- Minerals and Myopathies.- Normal Muscle Energy Metabolism.- The Myopathy of Experimental Magnesium Deficiency.- The Myopathy of Phosphate Depletion.- Myopathy of Uremia.- Clinical Topics.- Abnormalities in Parathyroid Hormone Secretion in Primary and Secondary Hyperparathyroidism.- The Role of Abnormal Vitamin D Metabolism in X-Linked Hypophosphatemic Rickets and Osteomalacia.- Calcium and Phosphate Metabolism in Sarcoidosis.- Effect of Calcitriol on Serum 1,25(OH)2D3 Levels and on Renal Phosphorous Threshold in X-Linked Hypophosphatemic Rickets.- Miscellaneous.- Impaired Hormonal Stimulation in Isolated Hepatocytes of Phosphorous Depleted Rats.- Hyperlipoproteinemia in Phosphate Depletion.- Stimulation of Cardiac Contractility by Catecholamines is Diminished in Experimental Uremia.- Influence of Calcium and Calcium Regulating Hormones on Renal Compensatory Growth.- Changes in Tissue Calcium Content During Gentamicin Acute Renal Failure.- Nuclear Magnetic Resonance.- Phosphorus Metabolites by NMR.- Applications of Nuclear Magnetic Resonance (NMR) in Nephrology.