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Phospholipid Metabolism in Apoptosis / Edition 1
     

Phospholipid Metabolism in Apoptosis / Edition 1

by Peter J. Quinn, Valerian E. Kagan
 

ISBN-10: 0306467828

ISBN-13: 9780306467820

Pub. Date: 05/31/2002

Publisher: Springer US

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the

Overview

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the subject of focused research effort. It is clear that cell membrane structure and properties play an early part in the induction process. There is increasing evidence that the arrangement of polar lipids in the membrane lipid matrix is an important factor coupled with the homeostatic mechanisms responsible for preserving membrane lipid composition and asymmetry. Changes in membrane permeability are also likely to be involved, possibly as a direct consequence of disturbances in the lipid bilayer matrix.
The purpose of this volume is to examine the involvement of membrane lipids in early events of apoptosis. In particular, the role of phospholipids in mihondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signalling processes in early apoptotic events are reviewed by current researchers in these fields.

Product Details

ISBN-13:
9780306467820
Publisher:
Springer US
Publication date:
05/31/2002
Series:
Subcellular Biochemistry Series , #36
Edition description:
2002
Pages:
340
Product dimensions:
6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Lipid Metabolism and Release of Cytochrome c from Mitochondria1
Interaction between Cytochrome c and Oxidized Mitochondrial Lipids19
Plasma Membrane Phospholipid Asymmetry39
Apoptosis by Phosphatidylserine in Mammalian Cells61
Phosphatidylserine Peroxidation during Apoptosis79
Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death97
Oxidized LDL-induced Apoptosis123
Induction of Apoptosis by Redox-cycling Quinones151
Apoptosis Induced by Ionizing Radiation171
Ceramidases in the Regulation of Ceramide Levels and Function187
Effect of Ceramides on Phospholipid Biosynthesis and Its Implication for Apoptosis207
Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis229
Cellular Signaling by Sphingosine and Sphingosine 1-phosphate245
Ceramide in Regulation of Apoptosis269
Lipid Signaling in CD95-mediated Apoptosis285
Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis309
Index335

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