In the last few years ways of thinking in psychiatry have undergone considerable change thanks to advances in the fields of morphology and plasticity of the CNS, particularly with regard to schizophrenic and mood disorders. In addition, the rapid and considerable development of neuroimaging techniques (CT, MRI, PET and computerized EEG) and of molecular genetics (through DNA recombinant meth odologies) have widened the approach to these disorders in a way unimagined a few years ago. These advances and the new etiopathogenetic hypotheses that have sprung from them were the central theme of the Second International Meeting on Schizophre nia "Morphology and Plasticity of the Central Nervous System - A Challenge for Psychiatry of the Nineties" which was organized by the Association for Research on Schizophrenia (ARS), the Schizophrenia Research Center of the Institute of Psychiatry of the University of Milan and the T. and F. Legrenzi Foundation, held in Milan on October 22-24, 1987. This book contains the contributions from participants of the meeting, which took place in a warm and friendly atmosphere and marked by lively and exhaustive discussions on the various papers. The contributions were recently revised for the present publication. We would like to express our appreciation to the book's contributors for the high quality of their reports.
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Table of ContentsSection 1: Schizophrenia: The Impact of Neuroimaging Techniques.- 1. Structural and developmental abnormalities in schizophrenia assessed with MRI.- 2. Brain morphology in schizophrenia by magnetic resonance imaging.- 3. Brain density patterns in schizophrenia.- 4. Lateral ventricular size and clinical features in schizophrenia.- 5. Hippocampal metabolic function in schizophrenia.- Section 2: Affective Disorders: The Impact of Neuroimaging Techniques.- 6. CT and MRI findings in affective disorders: clinical and research implications.- 7. Neuromorphological correlates of mood disorders: focus on cerebral ventricular enlargement.- 8. Brain imaging with positron emission tomography in affective illness.- 9. The impact of starvation on brain morphology and function in eating disorders.- Section 3: The Impact of Neurophysiological Studies in Psychiatry.- 10. Neurometric subtyping of depressive disorders.- 11. Lateralization patterns of verbal stimuli processing in schizophrenia patients.- 12. EEG patterns in schizophrenia: a familial study.- 13. Some aspects of psychophysiological studies in psychiatry.- Section 4: The Impact of Genetic Studies in Psychiatry.- 14. Genetic marker studies in schizophrenia.- 15. Amish study of genetics of affective disorders.- 16. Affective disorders segregation structures according to clinical and pharmacological features.- 17. Psychiatric disorders in families of phenylketonuric patients.- Section 5: Plasticity and Vulnerability of the CNS in Psychiatric Disorders.- 18. Neuronal plasticity in the central nervous system: a pharmacological approach.- 19. A neurodevelopmental perspective on some epiphenomena of schizophrenia.- 20. Clinical investigations of plasma homovanillic acid concentrations.- 21. Glucose-6-phosphate dehydrogenase deficiency and psychoses.- 22. Early separation events and noradrenergic status during major depression.- 23. Vulnerability and plasticity of monoamine neurotransmitter systems in affective and personality disorders.- 24. Concluding remarks: plasticity and morphology of the central nervous system in schizophrenia and affective disorders.