Polycomb Group Proteins

Polycomb Group Proteins

by Vincenzo Pirrotta

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Product Details

ISBN-13: 9780128098226
Publisher: Elsevier Science
Publication date: 01/01/2017
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 372
File size: 52 MB
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About the Author

Dr. Pirrotta is a world leader in the area of polycomb group proteins. He attended Harvard University up to a postdoctorate level studying physical chemistry and molecular biology. He joined the new EMBL Laboratory in Heidelberg, studying gene regulation in bacteriophage lambda and then Drosophila molecular genetics. He proceeded from there to the Baylor College of Medicine, studying developmental biology, gene regulation and chromatin organization. After tenure at the University of Geneva, he joined Rutgers University in 2004 as part of a laboratory that studies polycomb proteins, epigenetic silencers, chromatin complexes, genomics and nuclear architecture.

Table of Contents

1. Introduction to Polycomb Group Mechanisms 2. The Role of RAWUL and SAM in Polycomb Repression Complex 1 Assembly and Function 3. The Chromodomain of Polycomb: Methylation Reader and Beyond 4. Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes 5. Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module 6. Cooperative Recruitment of Polycomb Complexes by Polycomb Response Elements 7. Polycomb Function and Nuclear Organization 8. Molecular Architecture of the Polycomb Repressive Complex 2 9. Polycomb Repressive Complex 2 Structure and Function 10. Regulation of PRC2 Activity 11. Activating Mutations of the EZH2 Histone Methyltransferase in Cancer 12. PcG Proteins in Caenorhabditis elegans 13. Global Functions of PRC2 Complexes

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