Population Genetics and Microevolutionary Theory / Edition 1 available in Hardcover
An elegant introduction to population genetics
Written in the context of new molecular techniques for genetic analysis, Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating today's molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics.
Logically organized into three main sections—population structure and history, genotype/phenotype, and selection/adaptation—the text stresses a multidimensional model of evolution throughout, examining how multiple factors working together lead to biological phenomena. Three simple premises of DNA behavior are used to derive population genetics theory, and quantitative genetics is discussed as a foundation for understanding natural selection. Real examples illustrate concepts, with many examples taken from human genetics and evolution.
Population Genetics and Microevolutionary Theory also features:
- An introduction to background material
- A conclusion providing a handy overview of the field and its modern applications
- Review questions and answers at the end of each chapter
- An appendix on genetic survey techniques
- An appendix on statistical analysis and theory
- Helpful general references and Internet links
Written in a clear and accessible manner, without complex mathematical equations, Population Genetics and Microevolutionary Theory gives graduate and advanced undergraduate students an elegant introduction to this key field of modern biology.
|Edition description:||New Edition|
|Product dimensions:||7.20(w) x 10.10(h) x 1.50(d)|
About the Author
ALAN R. TEMPLETON, PhD, is Charles Rebstock Professor of Biology at Washington University in St. Louis, with joint appointments in Genetics and Biomedical Engineering.
Table of Contents
Description of Revised Content of Population Genetics andMicroevolutionary Theory
Chapter 1. Fuse current chapters 1 and 2 into a singlechapter entitled: “Population Genetics: Scope,Premises, and The Hardy-Weinberg Model ofMicroevolution.”
I would delete the section on “Methodological approachesin population genetics” that appears in the current Chapter1, and the example of Darwin’s finches would be deferred tothe chapters dealing with natural selection. This would allowme to expand the section on linkage disequilibrium that iscurrently in Chapter 2. In particular, I would go intoadditional measures of linkage disequilibrium such as r2and DUO, a recent vector measure of disequilibrium. I wouldalso define haplotypes in this new fused chapter, and show howlinkage disequilibrium arises in haplotype blocks and can also beused to detect them. Also, the construction and meaning ofextended haplotypes of indeterminate length will be introducedhere.
Chapter 2 (Currently Chapter 3). Systems of Mating. Few changes are required in this chapter. I will insert abrief discussion of the work of Keller et al (Genetics 189:237-249, 2011) that shows that pedigree inbreeding due to distantancestors can be estimated from runs of homozygosity using markersscattered across the entire genome.
Chapter 3 (Currently Chapter 4 and part of Chapter 5). Genetic Drift. A box will be inserted on the diffusionequation approximation to genetic drift. I will add a newsection on the use of effective sizes in conservation biology,focusing on effective sizes in African rhinos. Finally, Iwill move the part about the neutral theory of evolution (Currentlyin Chapter 5) to the end of the revised Chapter 3, but I willdelete the section on newly arisen mutations that is currently atthe beginning of Chapter 5.
Chapter 4. (Currently part of Chapter 5). Coalescence. I will update the examples used in the currentbook with more recent examples. Such an update isparticularly needed for the discussion of the infinite sites modeland the role it plays in coalescent models. The section onrecombination and coalescence also needs updating. A newsection will be inserted on coalescence and effective populationsize in order to integrate this chapter more thoroughly with theprevious chapter.
Chapter 5 (Currently Chapter 6). Gene Flow and PopulationSubdivision. Much of the material requires no updating,except for the substitution of more recent examples. A newsection on using extended haplotypes to trace gene flow will beinserted, and a second new section on Bayesian Assignmentmodels and parentage analysis will end the revised chapter.
Chapter 6 (Currently Chapter 7). Gene Flow and PopulationHistory. This chapter needs to be thoroughly rewritten. The section on ancient DNA will be expanded and new examples given,focusing on archaic humans. The section on multi-locusassociations will be updated, particularly with respect toprincipal components, and a new section on landscape genetics willbe inserted. The section on population trees needs to berewritten in light of new statistical developments in thisarea. A new section on Approximate Bayesian Computation inphylogeography will be inserted, along with a comparison of ABCwith multi-locus nested clade analysis showing their relativestrengths and weaknesses. There will also be a discussion ofskyline plots and its relationship to coalescence.
Chapter 7 (Currently Chapters 8 and 9). ClassicalQuantitative Genetics. No major revisions are needed in termsof the material, but I intend to fuse the current chapters 8 and 9into one, eliminating some redundancies and shortening the materialcurrently found in Chapter 9.
Chapter 8 (Currently Chapter 10). QuantitativeGenetics: Measured Genotypes. This chapter will be extensively rewritten and reorganized. It will deal with admixture mapping, linkage mapping, andgenome-wide association studies, followed by an updated treatmentof candidate loci. The updated section on candidate loci willalso include a discussion of gene expression arrays and theiranalysis.
Chapter 9 (Currently Chapter 11). Natural Selection. Very little revision is needed here, just a few updatedreferences.
Chapter 10 (Currently Chapter 12). Interactions of NaturalSelection with Other Evolutionary Forces. The firsthalf of this chapter will be mostly the same. A newdiscussion of coadapted gene complexes will be made, emphasizingnew developments in their detection and usefulness. Thesection on interactions with drift and mutation will be expanded,particularly with respect to genome-wide measures of detectingnatural selection and the many new developments and applications inthis area.
Chapter 11 (Currently Chapter 13). Units and Targets ofSelection. The main revision will be to substitute newerexamples for some of the ones currently in this chapter.
Chapter 12 (Currently Chapter 14). Selection inHeterogeneous Environments. A section on epigeneticadaptation to changing environments will be added. Thediscussion about Darwin’s finches would be moved here as anexample of selection in a temporally heterogeneousenvironment. A new section will be inserted about usinggenome-wide markers to detect local selection and ecologicalgenomics.
Chapter 13 (Currently Chapter 15). Selection inAge-Structured Populations. I will expand the section on lifehistory evolution to discuss the concepts of elasticity andsensitivity and their interactions with pleiotropy. A newsection on effective size in age-structured populations will beadded.
Appendix 1. Genetic Survey Techniques. Thisappendix needs to be updated given the technological advances thathave been made.
Appendix 2. Probability and Statistics. I willexpand the section on Bayesian inference to discuss the role ofcomputer simulations in generating posterior probabilities. This will be useful since the text will now discuss programs suchas STRUCTURE and ABC
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"...enjoyable to read...will certainly find its place on the shelves of those interested...[in] alternative viewpoints..." (American Journal of Human Biology, May/June 2007)