Reviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: This book provides an overview of the process of preclinical drug development for students and professionals either in or about to enter the field. The chapters provide an overall framework for the process, then focus on various in silico, in vitro, and in vivo approaches.
Purpose: The book presents a working knowledge of these various areas and approaches and provides links to more detailed treatments of these topics needed for a deeper understanding. Most chapters fully meet these goals.
Audience: The editors intend to provide an introduction to preclinical drug development for students in pharmacology, toxicology, and related disciplines, and also to serve as a refresher for those already in the field. The authors generally meet these goals.
Features: Given the broad scope of this book, and of some individual chapters, there are rather cursory treatments of topics in some chapters, but such topics are covered in more depth in other chapters. This complementarity is a strength of the book. Few references are from later than 2003, but they are thorough and effectively serve the reader who desires more information. Several chapters stress the growing appreciation of the role of transporters in drug disposition, and the known and potential importance of these proteins in pharmacology and toxicology.
Assessment: This is an interesting and effective survey of major issues in preclinical development, and of the experimental approaches and models applied to those issues.