ISBN-10:
0415271800
ISBN-13:
9780415271806
Pub. Date:
05/13/2004
Publisher:
Taylor & Francis
Predicting Chemical Toxicity and Fate / Edition 1

Predicting Chemical Toxicity and Fate / Edition 1

Hardcover

Current price is , Original price is $180.0. You

Temporarily Out of Stock Online

Please check back later for updated availability.

Item is available through our marketplace sellers.

Product Details

ISBN-13: 9780415271806
Publisher: Taylor & Francis
Publication date: 05/13/2004
Pages: 472
Product dimensions: 7.00(w) x 10.00(h) x 1.30(d)

Table of Contents

INTRODUCTION
Predicting Chemical Toxicity and Fate in Humans and the Environment - An Introduction

METHODOLOGY
Toxicity Data Sources
Calculation of Physicochemical Properties
Good Practice in Physicochemical Property Prediction
Whole Molecule and Atom Based Topological Descriptors
Quantum Chemical Descriptors in Structure-Activity Relationships - Calculation, Interpretation and comparison of Methods
Building QSAR Models - A Practical Guide

QSARs FOR HUMAN HEALTH ENDPOINTS
Prediction of Human Health Endpoints: Mutagenicity and Carcinogenicity
The Use of Expert Systems for Toxicity Prediction - Illustrated with Reference to the DEREK Program
Computer-Based Methods for the Prediction of Chemical Metabolism and Biotransformation within Biological Organisms
Prediction of Pharmacokinetic Parameters in Drug Design and Toxicology

QSARs FOR ENVIRONMENTAL TOXICITY AND FATE
An Exercise in External Validation: The Benzene Response-Surface Model for Tetrahymena Toxicity
Receptor-Mediated Toxicity: QSARs for Oestrogen Receptor Binding and Priority Setting of Potential Oestrogenic Endocrine Disruptors
Prediction of Persistence
QSAR Modelling of Bioaccumulation
QSAR Modelling of Soil Sorption
Application of Catabolic-Based Biosensors to Develop QSARs for Degradation

APPLICATION
The Tiered Approach to Toxicity Assessment Based on the Integrated Use of Alternative (Non-Animal) Tests
The Use of Quantitative Structure-Activity Relationships and Expert Systems to Predict Toxicity by Governmental Regulatory Agencies
A Framework for Promoting the Acceptance and Regulatory Use of (Quantitative) Structure-Activity Relationships.

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews