Progestins and Antiprogestins in Clinical Practice

Progestins and Antiprogestins in Clinical Practice

Hardcover(New Edition)



This comprehensive ready-reference guide thoroughly examines the physiological aspects of progestins and their role at the receptor level, focusing on reproductive activity, menopausal treatment, and related areas. The book presents vital research findings on the clinical use of progesterone and related derivatives, plus key applications of antiprogestins.
Illuminates progesterone's remarkable power in hormonal contraception and regulation of the hypothalamo-pituitary complex!
Written by more than 25 leading international experts on women's health, Progestins and Antiprogestins in Clinical Practice

  • explains the effects of long-term controlled progestin studies on breast tissue
  • discusses the nuclear localization of steroid hormone receptors
  • covers the relationship of CDK activity and cell proliferation
  • analyzes production of progesterone metabolites and precursors synthesized locally within the brain and in the endocrine glands
  • describes cardiovascular effects associated with combined oral contraceptives (COCs), highlighting carbohydrate and lipid metabolism and hematological factors
  • investigates the epidemiology of estrogen-induced endometrial hyperplasia and/or cancer
  • demonstrates cases in which minor structural modifications in some steroid molecules can affect biological function
  • explores several properties of progesterone and its natural derivatives
  • illustrates instances of cloning of the intracellular progesterone receptor (PR) in several species
  • assesses direct progesterone action in target tissues and indirect effects of progesterone regulation
  • surveys properties of widely used contraceptive steroids, such as norethindrone (NET) plus estradiol (E2), levonorgestrel (LNG) plus estradiol (E2), nestorone plus ethinyl estradiol (EE2), and NET acetate plus EE2
  • reviews the efficacy and safety of newer contraceptive strategies such as Norplant implants and vaginal rings
  • covers applications of RU486 (mifepristone)
  • and more!
  • Product Details

    ISBN-13: 9780824782917
    Publisher: Taylor & Francis
    Publication date: 11/28/1999
    Edition description: New Edition
    Pages: 424
    Product dimensions: 7.00(w) x 10.00(h) x 1.00(d)

    Table of Contents

    Physiological Aspects

    Structure of the Progesterone Receptor and Mode of Action of Progesterone,
    Anne Guiochon-Mantel Effects of Progesterone and Related Steroids in the Brain,
    Martine El-Etr, Michaël Schumacher, and Etienne-Emile Baulieu Effects of Progestin on the Breast: Regulation of Cell Cycle Progression by Progestins,
    Elizabeth A. Musgrove and Robert L. Sutherland Vaginal Progesterone: Direct Access to the Uterus, Physiological Hormone Replacement in Infertility and Gynecology,
    Dominique de Ziegler, Carlo Bulletti, and Ettore Cicinelli

    Pharmacology of Synthetic Progestins

    Pharmacology of Progestins: 17 -Hydroxyprogesterone Derivatives and Progestins of the First and Second Generation,
    Milan Rastislav Henzl and John A. Edwards Clinical Pharmacology of Third-Generation Gestogens,
    Kenneth Fotherby Pharmacology of New Progestogens: The 19-Norprogesterone Derivatives,
    Régine Sitruk-Ware and Kalyan Sundaram Hybrid Progestins: The Example of Dienogest,
    Michael Oettel and Cornelia Holz

    Clinical Applications


    Progestogens in Contraception: Third-Generation Pills,
    Ulysse J. Gaspard Levonorgestrel-Releasing Contraceptive Implants,
    C. Wayne Bardin Progestin-Releasing Intrauterine Devices,
    Tapani Luukkainen Contraceptive Vaginal Rings,
    Donna Shoupe and Daniel R. Mishell, Jr.
    Progestins for Emergency Contraception,
    André Ulmann


    Progestins in Hormonal Replacement Therapy and Prevention of Endometrial Disease,
    Régine Sitruk-Ware Progestins in Postmenopausal Women: Epidemiological Data on Relationships with Endometrial and Breast Cancer Risk,
    Timothy J. Key Progestins in Hormonal Replacement Therapy and Cardiovascular Risk,
    Régine Sitruk-Ware

    Breast Diseases

    Control of Estrogen's Effects by Progestins in Breast Cancer,
    Jorge R. Pasqualini Epidemiology and Treatment of Benign Breast Disease: Effect of Progestins on Breast Disease,
    Régine Sitruk-Ware and Geneviève Plu-Bureau

    Other Indications

    Therapeutic Use of Progestins: Practical Recommendations,
    Régine Sitruk-Ware

    Metabolic Effects of Progestins

    The Effect of Progestins on Plasma Lipids,
    Matti J. Tikkanen Hormonal Replacement Therapy and Glucose Metabolism in Postmenopausal Women,
    Sven O. Skouby


    Antiprogestins in Clinical Practice,
    Irving M. Spitz and Ann Robbins


    Pharmacokinetics of Progesterone Administered Orally and Parenterally,
    Frank Z. Stanczyk

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