Table of Contents Preface. In memoriam. Tumor cell proliferation, growth and differentiation. Can oncogene and tumor suppressor genes aid in assessing node-negative mammary tumors? (H. Höfler, M.J. Atkinson, A. Luz). New antibodies for the detection of the Ki-67 protein (M.H.G. Becker, J. Gerdes, G. Key). Flow cytometric DNA analysis in primary breast cancer: technical pitfalls and clinical applications (N. Harbeck et al.). Tumor invasion and metastasis. Structure and function of matrix metalloproteinases and their significance in breast cancer (H. Tschesche et al.). The role of cell adhesion molecules in metastasis formation by solid tumors (J.P. Johnson). Induction by urokinase-type plasminogen activator of c-fos gene expression in human ovarian cancer cells (I. Dumler, T. Petri, W.-D. Schleuning). Prognostic factors, new aspects of treatment. Synthetic peptides for the inhibition of cell-cell and cell-matrix adhesion (R. Haubner et al.). Reduction of metastatic tumor cells in bone marrow of breast cancer patients treated with monoclonal antibody (G. Schlimok, K. Pantel, G. Riethmüller). Integration of prognostic factors: Can we predict breast cancer recurrences? (G.M. Clark, S.D. Hilsenbeck). Urokinase (uPA) and PAI-1 as selection criteria for adjuvant chemotherapy in axillary node-negative breast cancer patients (F. Jänicke et al.). Angiogenin is a valuable prognostic factor in node-negative breast cancer (J. Bläser et al.). Index of authors. Keyword index.