This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P.
Table of ContentsIntroductory Remarks to the First Session.- Use of Prostaglandins in the Preparation of Blood Components.- Some Effects of Vasoactive Hormones on the Mammalian Red Blood Cell.- Use of PGE(1) in Preparation and Storage of Platelet Concentrates.- Prostaglandin E(1) and E(2): Qualitative Difference in Platelet Aggregation.- The Effect of Prostaglandins, Epinephrine, and Aspirin on Cyclic AMP Phosphodiesterase Activity of Human Blood Platelets and Their Aggregation.- Leukocyte Cyclic AMP: Pharmacological Regulation and Possible Physiological Implications.- Effect of Prostaglandins upon Enzyme Release from Lysosomes and Experimental Arthritis.- The Role of Prostaglandins in the Immune Response.- The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts.- Prostaglandin Release by Human Cells in vitro.- Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs.- Formation of Prostaglandins in the Skin Following a Burn Injury.- Prostaglandin Inhibition of Immediate and Delayed Hypersensitivity in vitro.- The Role of Prostaglandins in Microcirculatory Regulation and Inflammation.- Pro-Inflammatory Effects of Certain Prostaglandins.- Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents.- Contraction of Isolated Cutaneous Vascular Smooth Muscle and Its Response to Prostaglandins.- Interactions of Prostaglandin E(1) and Catecholamines in Isolated Vascular Smooth Muscle.- Cellular Aspects of Prostaglandin Synthesis and Testicular Function.- The Antihypertensive and Natriuretic Endocrine Function of the Kidney: Vascular and Metabolic Mechanisms of the Renal Prostaglandins.- Prostaglandins and the Microvascular System: Physiological and Histochemical Correlations.- Effect of Prostaglandins on Adrenergic Neurotransmission to Vascular Smooth Muscle.