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Prostate Cancer by Michael Shen

Prostate cancer is the most commonly diagnosed cancer in men and causes thousands of deaths annually. Many prostate tumors are slow growing and localized to the prostate, whereas others are more aggressive and spread to other areas of the body (e.g., bones). Work to better understand prostate cancer will lead to improved treatment options and more precise care for patients with this disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the pathogenesis and treatment of prostate cancer. The contributors review the normal development, anatomy, and histology of the prostate; the genetic, lifestyle, and dietary factors associated with prostate cancer risk; and the alterations in the genome, epigenetic landscape, transcriptional networks, and metabolic and signaling pathways that drive oncogenesis. The role of the tumor microenvironment in prostate cancer pathogenesis is covered, as are the molecular mechanisms of metastasis. The authors also discuss how mouse models and patient-derived tissues can be used to study aspects of the disease and accelerate the development of appropriate therapies.

Other topics include methods for diagnosing and monitoring prostate cancer, such as biomarker (e.g., serum PSA) testing, histopathological grading, and anatomical and molecular imaging techniques, as well as treatment options that are currently available and under development. Strategies that may prevent prostate cancer altogether (e.g., chemoprevention) are also described. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating this disease.

Product Details

ISBN-13: 9781621821649
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 11/30/2018
Series: Perspectives CSHL Series
Pages: 350

Table of Contents


Charles Sawyers

1. Introduction
Michael Shen and Mark Rubin

2. Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann

3. Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain

4. Epidemiology
Lorelei Mucci

5. Prostate Cancer Genetics
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles

6. Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck

7. Stem Cells and Cancer Stem Cells
Michael Shen

8. Pre-neoplastic Lesions
Angelo DeMarzo

9. Histopathology of Prostate Cancer
Peter A. Humphrey

10. Genomics
Mark Rubin

11. Transcriptional Regulation
Myles Brown

12. Epigenetics
Srinivasan Yegnasubramanian

13. Androgen signaling in prostate cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi

14. New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler,
and Wayne D. Tilley

15. DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen

16. Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero Jr., Ian M. Thompson Jr., Michael A. Liss, and Dharam Kaushik

17. Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson

18. Genetically Engineered Mouse Models of Prostate Cancer in the Post-Genomic Era
Juan M. Arriaga and Cory Abate-Shen

19. Pre-Clinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor

20. Preclinical and Co-Clinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi

21. Tumor Evolution
Francesca DeMichelis

22. Metabolism
Massimo Loda

23. Metastasis
George Thalmann

24. Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models and Therapy
Loredana Puca, Panagiotis J. Vlachosterogios, and Himisha Beltran

25. Biomarkers
Scott Tomlins

26. Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmalsi, and Robert E. Reiter

27. Immunotherapy
Charles Drake

28. Therapies for Advanced Disease
Semini Sumanasuriya and Johann De Bono