Proteases in Tissue Remodelling of Lung and Heart / Edition 1 available in Hardcover
- Pub. Date:
- Springer US
Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. Thus, the book should be a valuable source for both clinicians and researchers interested in protease function and/or diseases of lung and heart. Proteases in Tissue Remodelling of Lung and Heart: is devoted to proteases in lung and heart specifically and extensively, covers major diseases of the lung and heart, extensively introduces individual proteases (or families thereof), presents up-to-date patient-derived and experimental data, covers most aspects of protease function in disease.
About the Author
Nigel Hooper is Professor of Biochemistry in the School of Biochemistry and Molecular Biology at the University of Leeds, UK. He received his Ph.D in 1984 from the University of Leeds with a thesis on the "Metabolism of Neuropeptides by Cell-surface Peptidases" which stimulated his interest in proteases and paved the way for much of his subsequent research. He currently co-leads the Proteolysis Research Group at Leeds and among other topics, continues to study the structure and function of several cell-surface proteases, with a particular interest in their mode of attachment to the membrane. He has published over 90 research papers, edited 4 books and co-authored the widely acclaimed undergraduate textbook Instant Notes Biochemistry.
Table of ContentsPart I: Lung.
1. Human leukocyte elastase and cystic fibrosis; A.M. Cantin, A. Fournier, R. Leduc. 2. Matrix metalloproteinases in inflammation of the lung; Y. St-Pierre, C. Van Themsche. 3. Proteases in interstitial lung diseases; A. Wille, T. Welte, F. Bühling. 4. Matrix metalloproteinase inhibitors in cancer therapy; W. T. Purcell, M. Hidalgo. 5. The role of proteases in the pathogenesis of lung emphysema; H. Golpon, T. Köhnlein, T. Welte.
Part II: Heart.
6. Cardiac remodeling in pressure overload hypertrophy; U. Seeland, M. Böhm. 7. Ischemia / myocardial infarction: The role of matrix metalloproteinases; T. Takahashi, R.T. Lee. 8. Matrix metalloproteinases and myocardial remodeling in heart failure; Yun You Li, A.M. Feldman. 9. Proteases and arrhythmias; A. Goette, C. Röcken, K. Nepple, U. Lendeckel. 10. Impact of proteases in tissue engineering and regeneration; H. Mertsching, C. Puschman.