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Protein Chaperones and Protection from Neurodegenerative Diseases / Edition 1

Protein Chaperones and Protection from Neurodegenerative Diseases / Edition 1

by Stephan N. Witt, Vladimir Uversky
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Product Details

ISBN-13: 9780470569078
Publisher: Wiley
Publication date: 09/06/2011
Series: Wiley Series in Protein and Peptide Science Series , #7
Pages: 444
Product dimensions: 6.40(w) x 9.40(h) x 1.10(d)

About the Author

Stephan N. Witt is a Professor in the Department of Biochemistryand Molecular Biology at the Louisiana State University HealthSciences Center in Shreveport, Louisiana. He obtained his PhD inbiophysical chemistry from the California Institute ofTechnology. Dr. Witt is a member of the editorial board of CellStress and Chaperones. He has served on numerous NIH studysections, has authored over forty scientific publications, andedited a book on using yeast as a model for human disease. Hisresearch focuses on identifying genes and small molecules that canbe used against Parkinson's disease.

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Table of Contents




1 Intrinsically Disordered Chaperones and Neurodegeneration(Vladimir N. Uversky).

2 Redox Regulation of Protein Misfolding, Synaptic Damage,and Neuronal Loss in Neurodegenerative Diseases (TomohiroNakamura and Stuart A. Lipton).

3 Chaperone-Mediated Autophagy and Parkinson’s Disease(Marta Martinez-Vicente and Ester Wong).

4 Chaperone and Anti-Chaperone Properties of Synuclein:Implications for Development, Aging, and Neurodegenerative Disease(Makoto Hashimoto, Kazuanri Sekiyama, Akio Sekigawa, andMasayo Fujita).

5 The Ubiquitin–Proteasome System in NeurodegenerativeDiseases: More than the Usual Suspects (AnneBertolotti).

6 Regulation of the Polyglutamine Androgen Receptor by theHsp90/Hsp70-Based Chaperone Machinery (Andrew P. Liebermanand William B. Pratt).

7 Amyloid Remodeling by Hsp104 (JamesShorter).

8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity(Daniel W. Summers, Katie J. Wolfe, and Douglas M.Cyr).

9 Modulation of Amyloid Propagation in Yeast by Hsp70 and itsRegulators and Chaperone Partners (Daniel C.Masison).

10 ALS and the Copper Chaperone CCS (Marjatta Son andJeffrey L. Elliott).

11 Emerging Area: TorsinA, a Novel ATP-Dependent FactorLinked to Dystonia (Michal Zolkiewski and Hui-ChuanWu).

12 Therapeutics: Harnessing the Power of Molecular andPharmacological Chaperones (David S. Gross, Ronald L. Kleinand Stephan N. Witt).


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