Protein Kinase C / Edition 1

Protein Kinase C / Edition 1

by Lodewijk V. Dekker
ISBN-10:
1441934197
ISBN-13:
9781441934192
Pub. Date:
09/29/2011
Publisher:
Springer US
Select a Purchase Option (Softcover reprint of hardcover 1st ed. 2004)
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Overview

Protein Kinase C / Edition 1

Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells.
This book is the only recent publication devoted entirely to Protein Kinase C and forms a major point of reference for those active in the field. In addition it will appeal to those with a general interest in biochemistry, cell biology, immunology and neurobiology.

Product Details

ISBN-13: 9781441934192
Publisher: Springer US
Publication date: 09/29/2011
Series: Molecular Biology Intelligence Unit Series
Edition description: Softcover reprint of hardcover 1st ed. 2004
Pages: 208
Product dimensions: 6.14(w) x 9.21(h) x 0.44(d)

Table of Contents

Prefaceix
1.Introduction1
The Protein Phosphorylation Reaction1
Protein Kinases1
Protein Kinase C2
Protein Kinase C Isotypes and Their Domain Structure2
Defining the PKC Family4
This Book5
2.Structure, Function and Membrane Interactions of C1 Domains8
C1 Domain Structure and Stereospecific Ligand Recognition9
Membrane Binding and Subcellular Localization of C1 Domains11
Typical C1 Domains in Proteins Other than PKC12
Atypical C1 Domains12
C1 Domains in the Context of Multidomain Signaling Proteins13
3.Structural and Functional Specialization of C2 Domains in Protein Kinase C16
C2 Domain Structure17
C2 Domain Interactions with Ligands20
Mechanism of Membrane Targeting of PKC by C2 Domains25
4.Regulation of Protein Kinase C by Membrane Interactions36
Protein Kinase C: At the Heart of Lipid Signalling36
The Three Cofactors: Phosphatidylserine, Diacylglycerol, and Ca[superscript 2+]37
Translocation of Protein Kinase C42
Phosphorylation: Regulator of Protein Kinase C's Subcellular Location44
5.Protein Kinase C Regulation by Protein Interactions49
Examples of PKC Binding Proteins51
Discussion59
6.Regulation of Protein Kinase C by Phosphorylation63
Phosphorylation at the Activation Loop64
Phosphorylation at the Turn Motif67
Phosphorylation at the Hydrophobic Site68
The Role of the Phosphoinositide 3-Kinase Pathway69
Regulation by Dephosphorylation70
Implications for Cellular Function71
Regulation of Protein Kinase C by Tyrosine Phosphorylation71
7.Down-Regulation of Protein Kinase C76
The Proteolytic Mechanism78
Role of Down-Regulation82
8.Protein Kinase C in Yeast: The Cell Wall Integrity Pathway87
Yeasts PKC Homologues87
Rho GTPases and PKC Activation88
S. cerevisiae Pkc1p and the Cell Integrity Pathway90
Cell Integrity Pathway and Cell Cycle91
Interaction with Other Pathways93
Function of Pck1p and Pck2p in S. pombe Cell Integrity and Cell Wall Biosynthesis93
9.Specificity in Atypical Protein Kinase C Signaling: The NF-[kappa]B Paradigm100
The NF-[kappa]B Pathway100
Adapters for the aPKCs to NF-[kappa]B Activation103
Functional Relevance of the aPKCs in the Ras-NF-[kappa]B Crossroad106
Specificity during Cell Signaling106
Blockade of NF-[kappa]B by the Endogenous aPKC Inhibitor Par-4109
10.Protein Kinase C: A Molecular Information Storage Device in Neurons114
Activity-Dependent Synaptic Plasticity114
Inhibitors of PKC Block LTP116
Activating PKC Mimics LTP117
Biochemical Studies118
Oxidative Modification of PKC118
Protein Kinase Substrates Phosphorylated during LTP119
Cerebellar Long-Term Depression121
PKC in Learning and Memory121
Changes in Activity, Cellular Distribution and Phosphorylation of Substrates122
Pharmacological Inhibition of PKC123
Isotype Specific PKC Knockout123
11.Involvement of PKC in the Sensation of Pain134
Role of PKC in Peripheral Nociception136
Sensitization of the Heat-Gated Current by PKC136
Desensitization of VR1 by Calcineurin138
Phosphorylation of VR1138
PKC Isotypes Involved in VR1 Phosphorylation139
PKC-[varepsilon] and Inflammatory Pain139
Actions of PKC on Voltage-Sensitive Na Currents140
Specific Involvement of PKC-[varepsilon] in Neuropathic Pain141
Conclusion: Peripheral Nociception141
Involvement of PKC in Central Pain Processing141
Protein Kinase C-[gamma] and Persistent Pain142
PKC Activity, Opioid Tolerance and Pathological Pain States Are Related142
12.The Protein Kinase C Gene Module: Cellular Functions in T Lymphocytes147
The PKC Kinases: A Gene Family of Nine Isotypes147
Regulation of PKC Activity in T Cells149
Signaling Specificity of PKC in T Cells--A Complex Affair150
Role of PKC in T Lymphocyte Physiology153
PKC and T Cell Activation153
T Cell Antigen Receptor153
Integrin Receptors155
Cytokine Receptors156
Are There any Other Critical Pathways Modulated by PKC157
Role of PKC in Lymphocyte Development157
Role of PKC in Lymphocyte Homeostasis158
PKCs in Lymphocyte Disorders159
Synopsis and Future Perspectives159
13.Protein Kinase C Isotype Function in Neutrophils165
Basic Cell Biological Properties of Neutrophils165
PKC Isotypes in Neutrophils168
Studying PKC Isotype Function in Neutrophils171
Molecular Targets of PKC in Neutrophils173
Index191

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