Protein Physics: A Course of Lectures

Protein Physics: A Course of Lectures

by Alexei V. Finkelstein, Oleg Ptitsyn


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Product Details

ISBN-13: 9780128096765
Publisher: Elsevier Science
Publication date: 07/12/2016
Series: Soft Condensed Matter, Complex Fluids and Biomaterials
Edition description: Updated
Pages: 528
Product dimensions: 6.00(w) x 9.00(h) x (d)

About the Author

Alexei V. Finkelstein is the Head of the Laboratory of Protein Physics at the Institute of Protein Research, Russian Academy of Sciences. He is also a Full Professor in Biophysics at the Pushchino Department of the Lomonosov Moscow State University. He won the National Prize of Russia in Science in 1999 and is a Howard Hughes Medical Institute International Research Scholar. He is the author of about 150 papers on protein physics.Oleg B. Ptitsyn (deceased 1999) was the Head of Protein Physics Laboratory at the Institute of Protein Research, Russian Academy of Sciences and a Visiting Scientist at the Laboratory of Experimental and Computational Biology, Molecular Structure Section, National Cancer Institute, USA. He was also a member of the European Academy of Sciences and winner of the National Prize of Russia in Science (1999). He authored about 250 papers on polymer and protein physics.Their laboratory is one of the most distinguished in the world for its work in protein physics. It is one of the few laboratories outside the USA to receive support from the Howard Hughes Medical Institute. Both scientists have very high international reputations, Professor Finkelstein is frequently invited to conferences in Europe and in the USA, as was Professor Ptitsyn before his recent death.

Table of Contents

Part I INTRODUCTION Lecture 1: Main functions of proteins Part II ELEMENTARY INTERACTIONS IN AND AROUND PROTEINS Lecture 2: Amino acid residues in proteins Lecture 3: Quantum mechanics, Pauli exclusion principle, and non-covalent interactions Lecture 4: Influence of water environment Lecture 5: Water, hydrophobicity and proteins Lecture 6: Influence of an aqueous environment on electrostatic interactions Part III SECONDARY STRUCTURES OF POLYPEPTIDE CHAINS Lecture 7: Secondary structure of polypeptides Lecture 8: Elements of statistical mechanics Lecture 9: Free energy of initiation and elongation of a-helices in a homopolypeptide Lecture 10: 20 + 2 + 1 gene-coded amino acids in proteins Part IV PROTEIN STRUCTURES Lecture 11: Fibrous proteins, their functions, their regular primary and secondary structures Lecture 12: Membrane proteins; peculiarities of their structure and function Lecture 13: Globular proteins Lecture 14: Structure of a-proteins Lecture 15: Classification of protein folds Lecture 16: What secondary structure can be expected for random and quasi-random amino acid sequences Part V COOPERATIVE TRANSITIONS IN PROTEIN MOLECULES Lecture 17: "Well-folded" and "natively disordered" (or "intrinsically disordered") proteins Lecture 18: Denaturation of globular protein: why is it an "all-or-none" transition Lecture 19: Protein folding in vivo and in vitro Lecture 20: Two-state folding of small proteins: kinetic analog of the thermodynamic "all-or-none" transition Lecture 21: Solution of "Levinthal paradox" Part VI PREDICTION AND DESIGN OF PROTEIN STRUCTURE Lecture 22: Protein structure prediction from amino acid sequences Lecture 23: Overview of approaches to prediction and recognition of tertiary structures of proteins from their amino acid sequences Part VII PHYSICAL BACKGROUND OF PROTEIN FUNCTIONS Lecture 24: Protein function and protein structure Lecture 25: Combination of elementary functions Appendix A.: Theory of coil-globule transitions in homopolymers Appendix B.: Theory of helix-coil transitions in homopolymers Appendix C.: Statistical physics of one-dimensional systems and dynamic programming Appendix D.: Random energy model and energy gap in the random energy model Appendix E.: How to use stereo drawings Problems & Solutions

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