Protein Prenylation, Part B

Protein Prenylation, Part B

by Elsevier Science

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Product Details

ISBN-13: 9780124159648
Publisher: Elsevier Science
Publication date: 11/08/2011
Series: Enzymes , #30
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 372
File size: 7 MB

About the Author

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology&Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.

Table of Contents

CAAX Processing and yeast a-factor biogenesis Jemima Barrowman and Susan Michaelis

Geranylgeranyltransferase-1 inhibitors Norbert Berndt, Andrew D. Hamilton and Saïd M. Sebti

Small molecule inhibitors of GGTase-I from the heterocycle library derived from phosphine catalysis Lai N. Chan, Masaru Watanabe, Ohyun Kwon and Fuyuhiko Tamanoi

Inhibition of Rab prenylation E. Anouk Stigter, Gemma Triola, Roger S. Goody, Herbert Waldmann

The Ras Converting Enzyme (Rce1p): Orthologs, Enzymology and Inhibitors Timothy M. Dore and Walter K. Schmidt

Cysmethynil, A Specific Small Molecule Inhibitor of Isoprenylcysteine Carboxylmethyl Transferase (Icmt) Mei Wang

The Isoprenoid Biosynthetic Pathway and Statins Sarah A. Holstein

Inhibition of Farnesyl and Geranylgeranyl Diphosphate Synthases Sarah A. Holstein and Raymond J. Hohl

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