The book presents fundamental knowledge and current discoveries associated with the structure and cellular function of the pulmonary vasculature. This book elucidates the following topics: dysregulated cellular pathways observed in experimental and human pulmonary hypertension; structure and function of the normal pulmonary vasculature; introduction of numerous particular forms of this illness; clinical characteristics of the illness in general, and its management in special circumstances. It is a unique book which integrates cardiac and pulmonary physiology and pathophysiology with clinical aspects of this disease. Description of dysregulated pathways affected by pulmonary hypertension has also been provided. The book elucidates the effects of hypoxia on the pulmonary vasculature and the myocardium as well. An introduction of the techniques of assessing pulmonary hypertension has also been presented in this book. Numerous forms of pulmonary hypertension have been elucidated in this book, which are particularly challenging in clinical practice (like pulmonary arterial hypertension related to systemic sclerosis). Towards the end, the book discusses special considerations related to the management of this disease in certain clinical scenarios like pulmonary hypertension in the seriously ill.