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Basic Books
Purine and Pyrimidine Metabolism in Man VI

Purine and Pyrimidine Metabolism in Man VI

by K. Mikanagi


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Purine and Pyrimidine Metabolism in Man VI

These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan, July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth'in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.

Product Details

ISBN-13: 9780306432347
Publisher: Basic Books
Publication date: 01/01/1989
Series: Advances in Experimental Medicine and Biology Series , #25
Pages: 566

Table of Contents

Biochemistry of Enzymes in Purine and Pyrimidine Metabolism.- Rat Liver Phosphoribosylpyrophosphate Synthetase: Existence as Heterogenous Aggregates and Identification of the Catalytic Subunit.- Potent and Specific Inhibitors of Mammalian Phosphoribosylpyrophosphate PRPP Synthetase.- PRPP and Purine Nucleotide Metabolism in Human Lymphoblasts with Both PRPP Synthase Superactivity and HGPRT Deficiency.- Purification of Rat Liver Amidophosphoribosyltransferase.- Paradoxical Effects of Glucagon on De Novo Purine Synthesis in Rat Liver: In Vitro Phosphorylation of Amidophosphoribosyltransferase.- Proliferative Effect of Insulin by Selective Gene Expression in Purine Metabolic Pathway in Primary Cultured Rat Hepatocytes.- Purine De Novo Synthesis and Inosinic Branch Point In Vivo in Different Tissues: A Biomathematical Model.- The Inosinic Branch Point and Its Hormonal Regulation: Evaluation through a Mathematical Model.- Kinetic Properties of IMP Dehydrogenase Purified from Rat Hepatoma 3924A.- Two Distinct target Sites on IMP Dehydrogenase in Chemotherapy.- A Study of Adenosine Deaminase and Its Conversion Factor in Human Serum.- Cytidine Deaminase from Human Spleen.- AMP Deaminase and Thymidine Kinase Deficiencies in A Mutant Mouse S49 Cell Clone.- Properties of Highly Purified Human T lymphoblast (MOLT-4) Deoxycytidine Kinase.- Cell Cycle Regulation of Ribonucleotide Reductase M2 Subunit Specific RNA in Wild Type and Mutant S49 Cells.- Phosphocreatine as a Possible Modulator of the Adenylate Pool.- Regulation of Soluble 5?-Nucleotidase I from Rabbit Heart.- Purine 5?-Nucleotidase — Its Reestimated Subunit Molecular Mass and Immunocytochemical Localization in Chicken Liver.- The Application of Affinity Chromatography for the Separation of “High Km” and “Low Km” 5?-Nucleotidase and Other AMP Metabolizing Enzymes.- Evidence for “Low Km” and “High Km” Soluble 5?-Nucleotidase in Human Tissues and Rat Liver.- Low 5?Nucleotidase Activity in Mononuclear Cells of Patients with Defect T-Cell function.- Stimulation by Glycerate 2,3-Bisphosphate: a Common Property of Cytosolic Purine 5?-Nucleotidase in Various Tissues.- Functional Characterization of Ecto-5?-Nucleotidase (Ecto-5?-NT) Positive and Negative Human Lymphocytes.- Anti-5?-Nucleotidase Antibodies Cause Human Peripheral Blood T Cells to Proliferate.- Erythrocyte Pyrimidine 5?-Nucleotidase: HPLC Assay, Observation on the Enzyme behavior.- Structure of Xanthine Dehydrogenase from Chicken and Rat Liver. Chemical Modification of NAD Binding Site with 5?-FSBA.- Interconversion between NAD-Dependent and O2-Dependent Types of Rat Liver Xanthine Dehydrogenase and Difference in Kinetic amd Redox Properties between Them.- Mammalian Xanthine Oxidoreductase — A Unique Enzyme among Hypoxanthine Hydroxylating Enzymes in Vertebrates.- Heterogeneity of the Toxic Mechanisms of Methylthioadenosine in Methylthioadenosine Phosphorylase Deficient Murine Lymphoma Cells.- Improved Assay Method of dTMP Synthase in Rat Liver and Its Application to Human Lung Cancer Cells.- Toxic Mechanisms of Deoxynucleosides.- Adenosine Deaminase Activity in Recipients of Bone Marrow from Immunodeficient Mice Homozygous for the Wasted Mutation.- Utilization of 2?-DeoxyNAD for ADP-ribose Transfer Reactions.- Profound Toxicity of Deoxyadenosine and 2-Chlorodeoxyadenosine toward Human Monocytes In Vitro and In Vivo.- The Mechanism of 2-Chlorodeoxyadenosine-lnduced Cell Death.- Artefacts due to Radiation-Induced Cell Damage in Pulse-Labeling Experiments Using Tritiated Nucleic Acid Precursors.- Reduced Purine Nucleotide Content and Poly(ADP-Ribose) Synthetase Activity in HPRT-Deficient Human Lymphoblasts.- Inability of Poly-ADP-Ribosylation Inhibitors to Protect Peripheral Blood Lymphocytes from the Toxic Effects of ADA Inhibition.- Characterization of Poly(ADP-ribose) Polymerase with Human Autoantibodies.- Mechanism of ATP Catabolism Induced by Deoxyadenosine and Other Nucleosides in Adenosine Deaminase-lnhibited Human Erythrocytes.- DeoxyGTP Accumulates in Thymocytes, but not in T or B Lymphocytes in Simulated PNP Deficiency.- The Mechanism of Deoxyguanosine Mediated Toxicity in Proliferating Human Peripheral Blood T Lymphocytes.- Anti-Cancer Purine and Pyrimidine Analogs, Basic Research.- Metabolism of Guanosine and Its C-8 Substituted Analogues in Human Lymphocyte Cytoplasm.- Selective Toxicity of Purine Nucleosides to Human Leukaemic Cells.- Recovery of the Acitivities of IMP Dehydrogenase and GMP Synthase after Treatment with Tiazofurin and Activicin in Hepatoma Cells In Vitro.- Channeling of IMP into Guanylate Synthesis in the Growth Program of Hepatoma 3924A Cells.- Incorporation of 5-Fluorouracil into Nucleotide Sugars and the Effect on Glycoconjugates in Rat Hepatoma Cells and Hepatocytes.- Transport and Intracellular Metabolism of Fluorinated Pyrimidines in Cultured Cell Lines.- Fluoropyrimidine Metabolism in Human Head and Neck Cancer Xenografts and Murine Colon Tumors.- Reduction of Ara-C Cytotoxicity in HL 60 Cells by Addition of Deoxycytidine, Cytidine or Increased Level of Cytidine Deaminase.- Intracellular Pharmacokinetics of N4-Behenoyl-1-?-D-Arabinofuranosyl-cytosine.- Sequential Combination of Methotrexate and 1-?-D-Arabinofuranosyl-cytosine Shows Synergistic Effect on the Generation of DNA Strand Breaks in a Human Promyelocytic Cell Line.- Synergistic Interaction between Etoposide and 1-?-D-Arabinofuranocyl-cytosine.- Ara-CTP Metabolism Following Hydroxyurea or Methotrexate Treatment in Human Leukemia Cell Lines.- Relationship between Intracellular dCTP/Ara-CTP Ratio and Cytotoxic Effect of Ara-C.- The Relationship between Dihydroorotic Acid Dehydrogenase and In Vitro and In Vivo Cytostatic Effects of Brequinar Sodium (DUP-785; NSC 368390).- Estimation of the In Vitor and In Vivo Inhibitory Effects of Antifolates upon Thymidylate Synthase (TS) in Whole Cells.- Anti-Viral Purine and Pyrimidine Analogs.- Effects of 3?-Azido-3?-Deoxythymidine and the Deoxynucleoside Triphosphate Pools of Cultured Human Cells.- 2-Halo-2?,3?-Dideoxyadenosines: Metabolically Stable Dideoxynucleosides with Activity against the Human Immunodeficiency Virus (HIV).- 3?-Azido-3?-Deoxythymidine and Acyclovir: Antiviral Nucleoside Analogues with Unusual Cell Membrane Permeation Properties.- The Antiretroviral and Cytostatic Activity, and Metabolism of 3?-Azido-2?,3?-Dideoxythymidine, 3?-Fluoro-2?,3?-Dideoxythymidine and 2?,3?-Dideoxycytidine are Highly Cell Type-Dependent.- Dideoxycytidine Metabolism in Wild Type and Mutant CEM Cells Deficient in Nucleoside Transport or Deoxycytidine Kinase.- Adenosine and Adenosine Receptors.- Coordinate Regulation of Adenosine A1 and A2 Receptors.- A1 and A2 Adenosine Receptors in Synovial Cells from Patients with Rheumatic Diseases.- Use of Purine Nucleotide and Nucleoside Metabolising Enzymes as Tools to Determine the Presence of Purinergic Nerve Transmission in Smooth Muscle.- Influence of Succinylpurines on the Binding of Adenosine to a Particulate Fraction of Rat Cerebral Cortex.- Protective Effects of Cyclohexyladenosine Following Cerebral Ischemia in the Gerbil Hippocampus.- Differential Expression of Ecto-Nucleotide Metabolic Enzymes during Immunoglobulin Gene Rearrangements in Human Pre-B-Cells.- Purine Metabolism in Various Cells.- Optimised Conditions for the Routine HPLC Separation of Nucleotides in Cell Extracts.- Qualitative and Quantitative Studies on the Nucleotides of Intestinal Mucosa.- Relationship between Extracellular and Intracellular Nucleotide Metabolism in Human Lymphocytes.- Effect of Some Purine Metabolites Contained in Oyster on Platelet Aggregation.- Enzymes of Purine Nucleotide Metabolism in Mature Cultures of Rat Brain Neurons.- Nucleotide Pyrophosphatase Antagonizes Contractions due to the Twitch Component of the Sympathetic Nerve Response and to Applied ATP in the Guinea-Pig Vas Deferens.- Regulation of Purine Nucleotide Metabolism in Hypoxic Liver and Intestine of Rats: Radical Scanvenging Effects of Allopurinol and Oxypurinol.- Localization of Xanthine Dehydrogenase in Liver.- Determination of Allantoin in Mammalian Tissues.- Nucleoside Transport.- Characterization of Nucleoside Transport during Leukemic Cell Differentiation.- Exprssion of a Novel High Affinity Purine Base Transport System in Mutant Mouse S49 Cells does not Require a Functional Nucleoside Transporter.- Characterization of a Mutant Clone of Leishmania Donovani Deficient in Folate Transport.- Influence of the Temperature on Hypoxanthine Transport through Human Erythrocyte Membranes.- Adenine Uptake by Human Erythrocytes.- Contributors.

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