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Quality in Laboratory Hemostasis and Thrombosis / Edition 1
     

Quality in Laboratory Hemostasis and Thrombosis / Edition 1

by Steve Kitchen, John D. Olson, F. Eric Preston, Frits R. Rosendaal
 

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ISBN-10: 140516803X

ISBN-13: 9781405168038

Pub. Date: 01/20/2009

Publisher: Wiley

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses

Overview

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing.

Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.

Product Details

ISBN-13:
9781405168038
Publisher:
Wiley
Publication date:
01/20/2009
Pages:
232
Product dimensions:
7.60(w) x 9.80(h) x 0.90(d)

Table of Contents

Contributors vii

Foreword Frits R. Rosendaal x

Preface xii

1 General Quality Planning in the Hemostasis Laboratory John D. Olson 1

2 Hemostasis Test Validation, Performance and Reference Intervals Richard A. Marlar 9

3 International Standards in Hemostasis Trevor W. Barrowcliffe 19

4 Sample Integrity and Preanalytical Variables Dorothy M. Adcock 31

5 Internal Quality Control in the Hemostasis Laboratory Steve Kitchen F. Eric Preston John D. Olson 43

6 External Quality Assessment in Hemostasis: Its Importance and Significance F. Eric Preston Steve Kitchen Alok Srivastava 51

7 Initial Evaluation of Hemostasis: Reagent and Method Selection Wayne L. Chandler 63

8 Point-of-Care Testing in Hemostasis Chris Gardiner Samuel Machin Ian Mackie 72

9 Assay of Factor VIII and Other Clotting Factors Steve Kitchen F. Eric Preston 81

10 Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders Stefan Lethagen Marianne Schwartz Lars Bo Nielsen 90

11 Standardization of D-dimer Testing Guido Reber Philippe de Moerloose 99

12 Diagnostic Assessment of Platelet Function Paquita Nurden Alan Nurden 110

13 Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis Emmanuel J. Favaloro 125

14 Laboratory Analysis of von Willebrand Disease: Molecular Analysis Anne Goodeve Ian Peake 137

15 Dilemmas in Heritable Thrombophilia Testing Isobel D. Walker Ian Jennings 147

16 Evaluation of Antiphospholipid Antibodies Michael Greaves 160

17 Monitoring Heparin Therapy Marilyn Johnston 170

18 Monitoring Oral Anticoagulant Therapy Armando Tripodi 179

19 Monitoring New Anticoagulants Elaine Gray Trevor W. Barrowcliffe 190

20 Detecting and Quantifying Functional Inhibitors in Hemostasis Bert Verbruggen Irena Nováková Waander van Heerde 198

Index 209

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