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Quality in Laboratory Hemostasis and Thrombosis / Edition 2

Quality in Laboratory Hemostasis and Thrombosis / Edition 2

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Product Details

ISBN-13: 9780470671191
Publisher: Wiley
Publication date: 05/13/2013
Pages: 290
Product dimensions: 7.30(w) x 9.80(h) x 0.80(d)

About the Author

Dr Steve Kitchen, Clinical Scientist, Sheffield Hemophila and Thromobosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK.

John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA.

F. Eric Preston, Emeritus Professsor of Hematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK.

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Table of Contents

Contributors, vii

Foreword, x

Preface, xii

Steve Kitchen, John D. Olson, & F. Eric Preston

Part 1: General Quality Program

1 General quality planning in the hemostasis laboratory, 3
John D. Olson

2 Hemostasis test validation, performance, and referenceintervals: international recommendations and guidelines, 12
Richard A. Marlar

3 Causes of errors in medical laboratories, 22
Giuseppe Lippi & Emmanuel J. Favaloro

4 International standards in hemostasis, 32
Trevor W. Barrowcliffe & Anthony R. Hubbard

5 Sample integrity and preanalytical variables, 45
Dorothy (Adcock) Funk

6 Internal quality control in the hemostasis laboratory,57
Steve Kitchen, F. Eric Preston, & John D. Olson

7 External quality assessment in hemostasis: its importance andsignificance, 65
F. Eric Preston, Steve Kitchen, & Alok Srivastava

8 The unique challenges of hemostatic testing in children,77
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, &Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial evaluation of hemostasis: reagent and methodselection, 95
Wayne L. Chandler

10 Assay of factor VIII and other clotting factors, 105
Steve Kitchen & F. Eric Preston

11 Application of molecular genetics to the investigation ofinherited bleeding disorders, 115
Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen

12 Detecting and quantifying acquired functional inhibitors inhemostasis, 124
Bert Verbruggen, Myriam Dardikh, & Britta Laros-vanGorkom

13 Standardization of d-dimer testing, 136
Guido Reber & Philippe de Moerloose

14 Point-of-care testing in hemostasis, 147
Chris Gardiner, Dianne Kitchen, Samuel Machin, & IanMackie

Part 3: Quality in Testing for Platelet Function and vonWillebrand Disease

15 Diagnostic assessment of platelet function, 159
Paquita Nurden, Alan Nurden, & MartineJandrot-Perrus

16 Laboratory evaluation of heparin-induced thrombocytopenia,174
Theodore (Ted) E. Warkentin & Jane C. Moore

17 Laboratory evaluation of von Willebrand disease: phenotypicanalysis, 192
Emmanuel J. Favaloro

18 Laboratory analysis of von Willebrand disease: molecularanalysis, 204
Anne C. Goodeve & Ian R. Peake

Part 4: Quality in Thrombophilia Testing and MonitoringAnticoagulation

19 Quality issues in heritable thrombophilia testing, 219
Isobel D. Walker & Ian Jennings

20 Evaluation of antiphospholipid antibodies, 233
Michael Greaves

21 Monitoring heparin therapy, 244
Marilyn Johnston

22 Monitoring oral anticoagulant therapy with vitamin Kantagonists, 253
Armando Tripodi

23 Monitoring new anticoagulants, 264
Elaine Gray & Trevor W. Barrowcliffe

Index, 273

What People are Saying About This

From the Publisher

"There are particularly useful chapters covering the monitoring of heparin and oral anticoagulation. The book is pretty up to date and even covers the monitoring of new anticoagulants." (The Bulletin of the Royal College of Pathologists, July 2010)

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