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Quinolone Antimicrobial Agents / Edition 2
     

Quinolone Antimicrobial Agents / Edition 2

by David C. Hooper, John S. Wolfson
 

ISBN-10: 1555810594

ISBN-13: 9781555810597

Pub. Date: 10/28/1993

Publisher: ASM Press

An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years.
• Compiles the current information on a larger number of compounds and their expanding clinical applications.
• Provides a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical

Overview

An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years.
• Compiles the current information on a larger number of compounds and their expanding clinical applications.
• Provides a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical communities.
• Includes information on the treatment of intra-abdominal infections and infections caused by intracellular pathogens and the use of fluoroquinolones in intensive care unit infections and in pediatrics.
• Covers adverse effects, including QT prolongation, phototoxicity, effects on cartilage, and central nervous system effects.

Product Details

ISBN-13:
9781555810597
Publisher:
ASM Press
Publication date:
10/28/1993
Edition description:
REV
Pages:
549
Product dimensions:
10.00(w) x 7.01(h) x (d)

Table of Contents

Contributorsvii
Prefacexi
Introductionxiii
I.Mechanisms and Spectrum of Antibacterial Activity and Resistance
1.Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not3
2.Mechanisms of Quinolone Action19
3.Mechanisms of Quinolone Resistance41
4.Quinolones and Eukaryotic Topoisomerases69
5.Activity In Vitro of the Quinolones91
II.Pharmacology
6.Pharmacokinetics of Fluoroquinolones115
7.Drug-Drug Interactions133
8.Pharmacodynamics of Quinolone Antimicrobial Agents147
III.Clinical Applications
9.Treatment of Urinary Tract Infections159
10.Use of Quinolones for Treatment of Sexually Transmitted Diseases171
11.Treatment and Prophylaxis of Gastroenteritis193
12.Treatment of Intra-Abdominal Infections217
13.Treatment of Community-Acquired Respiratory Tract Infections227
14.Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage245
15.Treatment of Osteomyelitis and Septic Arthritis251
16.Treatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial Agents259
17.Treatment of Bacterial Meningitis and Other Central Nervous Systems Infections275
18.Treatment of Eye Infections291
19.Treatment of Skin and Soft Tissue Infections311
20.Treatment of Intracellular Infections323
21.Fluoroquinolones in Intensive Care Unit Infections337
22.Quinolones in Pediatrics343
23.Quinolone Resistance and Its Clinical Relevance355
24.Veterinary Use of Quinolones and Impact on Human Infections387
IV.Adverse and Other Effects
25.Adverse Effects407
26.QT Prolongation with Quinolone Antimicrobial Agents421
27.Effects on Connective Tissue Structures441
28.Phototoxicity Due to Fluoroquinolones451
29.Central Nervous System Toxicity461
30.Effects of Quinolones on the Immune System467
Index475

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